Data Management and Statistics Core
The Data Management and Statistics (DMS) Core, led by Dr. Dan Gillen, is responsible for providing efficient, comprehensive, and secure data management and analytic support for the ADRC. The primary mission in the DMS Core is to facilitate clinical and basic science research in the area of Alzheimer’s disease.
As a statistician, Dr. Gillen’s goal is “to quantify the degree of uncertainty in relationships within the data with the ultimate goal of making general statements about the aging population.”
Identifying and applying the most appropriate statistical analyses to answer a research question is often one of the most challenging aspects of completing a study. Hence, the ADRC makes Dr. Gillen and his team of statisticians available to consult on study design and conduct sophisticated analyses. As Dr. Gillen explains, “Faculty and staff in the DMS Core are experts in clinical and observational methods who value collaborative science and seek long-term collaborations for advancing knowledge in the field.”
The UCI ADRC collects and maintains clinical and neuropathological data to support a variety of scientific studies.
Longitudinal clinical data from participants
- Basic demographics
- Medical history
- Family history
- Physical and neurological exam
- APOE genotype
- Consensus diagnosis
- Comprehensive neuropsychological testing battery
Neuropathological data from participants
- Cause of death
- Brain weight
- Braak staging
- Vascular findings
- Neuropathological diagnosis
- Presence/absence of neuropathological features of most dementias
- Longitudinal clinical data is available in many cases
Finally, the DMS Core is responsible for transferring our ADRC data to the National Alzheimer’s Coordinating Center which houses and makes available data from all 29 Alzheimer’s Disease Centers to researchers worldwide.
Data Management and Statistics Core Members
- Dan Gillen, Ph.D., Core Leader
- Maria Corrada, Sc.D., Core Investigator
- Michael Phelan, Ph.D., Core Investigator
- Dan Hoang, Data Manager
- Nadim Madi, Program Analyst
For detailed information about the data, statistical, and other resources available to investigators through the UCI ADRC, visit dmsc.adrc.uci.edu.