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Dr. Ira Lott, Director of UCI MIND Down Syndrome Program, featured in OC Business Journal

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Dr. Ira Lott, Director of the UCI MIND Down Syndrome Program, discussed the connection between Down syndrome and Alzheimer’s disease with the Orange County Business Journal this week.  Dr. Lott and his team conduct critical research studies with volunteer participants to improve understanding of brain aging and dementia in Down syndrome. Click here to read the article > To learn more about studies in Down syndrome and Alzheimer’s disease, click here >

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Novel genetics research opens door to potential new therapies for dementia

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UCI MIND faculty member, Dr. Vivek Swarup, and colleagues at UCLA, Takeda Pharmaceutical Co. Ltd. in Japan, Emory University School of Medicine, Harvard Medical School, and the Perelman School of Medicine at the University of Pennsylvania, published novel findings yesterday in Nature Medicine on two major groups of genes associated  with Alzheimer’s disease and frontotemporal dementia and unraveled a novel microRNA, miR-203, as a master regulator of neuronal death. In human cell cultures containing AD-associated mutations, the researchers showed that certain experimental drugs altered the loss of brain cells associated with neurodegenerative disease. Dr. Swarup says, “I’m hopeful these important findings will bring us one step closer to effective new treatments…

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Dr. Blurton-Jones awarded grant to identify potential treatments for Alzheimer’s disease

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UCI MIND faculty member Dr. Mathew Blurton-Jones was awarded a $500,000 grant from Orange County Community Foundation to test 1200+ FDA-approved compounds for effectiveness in Alzheimer’s disease treatment. His lab seeks to find the top 20 genes and drugs that safely prevent brain damage caused by microglia, which are critical immune cells in the brain that ‘prune’ unnecessary neuronal connections, or synapses. In the brains of people with Alzheimer’s disease, damage can be caused by microglia ‘overpruning’ synapses, leading to loss of necessary connections. UCI News reports that Dr. Blurton-Jones and his team are “grateful to be the recipients of this…

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UCI MIND selected as Center of Excellence to conduct clinical trials in Down Syndrome and Alzheimer’s disease

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UCI MIND faculty member, Dr. Ira Lott, is one of the world’s leading experts in unraveling the link between Down syndrome and Alzheimer’s disease (Learn more in the Winter 2016 issue of MIND Matters). His team has been selected as a Center of Excellence for the new Down Syndrome Clinical Trial Network (DS-CTN) launched by LuMIND, a Down syndrome research foundation. As part of this important network, Dr. Lott and his team will receive funding to conduct clinical trials of promising therapies for participants with Down syndrome, at risk for Alzheimer’s disease. To learn more about the initiative and the…

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Dr. Joshua Grill discusses A4 Study results in Alzforum

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This week Alzforum posted coverage from the Alzheimer’s Association International Conference, including UCI MIND Director Dr. Joshua Grill’s presentation of data from The A4 Study (Anti-Amyloid Treatment in Asymptomatic Alzheimer’s Disease Study). In The A4 Study, a secondary prevention trial of late-onset Alzheimer’s disease, people with elevated amyloid had higher levels of memory complaints than those without elevated amyloid. To read the full article, click here > 

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Orange Coast Magazine calls upcoming conference a “Can’t-Miss” health event in OC

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Orange Coast Magazine​ just named our upcoming research conference in the “20 Can’t-Miss Health Events in O.C. To Keep You Healthy!” Don’t miss your chance to attend Trials Today, Treatments Tomorrow, Sept. 21 at the Irvine Marriott​. Tickets: http://bit.ly/alzconference or call 949.757.3720 x 3733. “Alzheimer’s affects more than 84,000 people in Orange County. This conference, hosted by the UC Irvine Institute for Memory Impairments and Neurological Disorders (UCI MIND) and Alzheimer’s Orange County, will bring world-renowned experts to Irvine to discuss progress in the battle against Alzheimer’s.” — Orange Coast Magazine  

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UCI MIND needs volunteers for clinical trials on Alzheimer’s disease

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UCI MIND Director Dr. Joshua Grill wrote an article for the Daily Pilot about the need for Alzheimer’s clinical trial research participants in Orange County. Read an excerpt below, and click here for the full article > “Here in Orange County, we are home to the Alzheimer’s Disease Research Center, the UC Irvine Institute for Memory Impairments and Neurological Disorders (UCI MIND). And we are making progress. There will be one essential key to needed advances, however. You. We need more people to participate in research, especially clinical trials of promising treatments. Clinical trial participants in Alzheimer’s research, much like…

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