Our memories are imperfect treasures – dear to our hearts, but not necessarily accurate snapshots of reality. CNN's Chief Medical Correspondent Dr. Sanjay Gupta talks to neurobiologist Michael Yassa about how memories are stored in the brain, why we forget, and what we’ve gotten wrong about how it’s supposed to work. To help understand the mechanisms of memory, we meet a woman who remembers absolutely everything... and a man who can’t even recall what he ate for breakfast. Plus, actionable tips for how we can keep our memories sharp at any age.
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Originally posted by Orange County Aging Services Collaborative (OCASC): We now have Mastering the Master Plan translated into Spanish, English, Vietnamese, and ASL! Please see below links to share with everyone you know. This event was hosted by the collaborative and the County of Orange on Nov 5th, 2021 to educate everyone about the CA Master Plan for Aging. It also included a town hall with elected officials. This is an important topic and this plan needs to be implemented at the local level. Do YOU know about the CA Master Plan for Aging? What are your elected officials doing…
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UCI MIND’s partner and sponsor of the Research And Mentorship Program (RAMP) HFC, led by Seth Rogen and Lauren Miller Rogen, has announced their annual convention for caregivers, CareCon. Learn more here >
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Originally posted on The Company of Biologists "First Person is a series of interviews with the first authors of a selection of papers published in Journal of Cell Science, helping early-career researchers promote themselves alongside their papers." UCI MIND trainee Gianna Fote was recently selected for an interview to discuss her latest publication. Read the full interview here, and learn about her publication here.
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Residential households in the U.S. can order one set of 4 free at-home tests from USPS. Here’s what you need to know about your order: Limit of one order per residential address One order includes 4 individual rapid antigen COVID-19 tests Orders will ship free starting in late January Fill in this form with your contact and shipping information to order your tests: https://special.usps.com/testkits
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Congratulations to UCI MIND member Dr. Claudia Kawas, who was just announced as the recipient of a UCI Academic Senate 2021-22 Distinguished Faculty Award. Dr. Kawas, who is a Professor of Neurology, will receive the Academic Senate Better World Award. To learn about her research studying longevity in the oldest-old, visit 90study.org.
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Contributed by Joshua Grill, PhD January 11, 2022 — Today the U.S Centers Medicare & Medicaid Services (CMS) announced their decision to cover monoclonal antibodies against the beta amyloid protein that accumulates in the brain of people with Alzheimer’s disease only in the setting of randomized controlled trials (read the announcement here). This Coverage with Evidence Development (CED) decision is open to public comment for 30-days before taking effect. The decision, if finalized, will to limit access to the one approved monoclonal antibody, Biogen’s drug aducanumab (Aduhelm), and any subsequently approved monoclonal antibodies, to Medicare beneficiaries who are participating in…
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Gianna Fote's work in the lab of Drs. Leslie Thompson & Joan Steffan, supported by the ADRC, was accepted to the Journal of Cell Science. Congrats to the entire team of researchers! Read more here >
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Here's to a great year of podcasting with our new series for caregiver stories, Spotlight on Care! Let's take a look at 2021: Top Episode Recognizing the Early Signs of Alzheimer's Disease with Bill Edwards was the most popular episode of Spotlight on Care in 2021. It was published on February 02 and has been downloaded 186 times. Listen to it here! 19 Episodes In 2021, Spotlight on Care published 10 hours of new content across 19 episodes. That’s 587 minutes or 35,256 seconds to be more precise. 2,311 Downloads In 2021, Spotlight on Care episodes were downloaded 2,311 times thanks…
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❄️Wishing you a joyous holiday season with our sincere appreciation for your trust & confidence in us as we research ways to make memories last a lifetime We wish you a New Year filled with Peace, Happiness & Hope Joshua D. Grill, PhD & the Faculty & Staff of UCI MIND
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In January 2022, the NIA’s Spanish language materials email list will officially launch with monthly emails on staying healthy as you age entirely in Spanish. The list will also highlight NIA’s Spanish resources, including print publications, videos, and web articles. If you signed up for the list in August, there is no need to subscribe again. If you haven’t signed up, you can subscribe here. Other new resources and materials from NIA that may be of interest to you and the communities you serve: Now in Spanish: Get Fit for Life Exercise and Physical Activity Guide for Healthy Aging. New videos on Healthy Aging…
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As a child in the early 1980s, I was enamored with My Little Pony, the colorful plastic horse figurines with long manes. I also had the brand’s Show Stable, which was parked in our TV room and filled with my beloved ponies. But as I progressed through grade school, I eventually packed up my stable and forgot about the toys I once loved. By late 2003, I hadn’t thought about my ponies for over 15 years. Then, VH1 ran a 1980s nostalgia show in which celebrities reminisced about bygone pop culture. An actress held up a My Little Pony figurine…
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Overactivity in the hippocampus, likely tied to lack of inhibition, underlies some age-related cognitive decline. Targeting those circuits shows early promise in slowing memory loss. By Emily Singer December 9, 2021 As we get older, our memory begins to fail in predictable ways. We’re more likely to confuse similar memories, for example, forgetting whether it was little Tim or Samantha who threw the turkey leg across the room at Thanksgiving, and whether that happened the same year the dog snatched the sweet potato pie. In experiments in the lab, old people can easily remember very different objects but have a…
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Alzheimer’s disease (AD) clinical trials require the enrollment of two people: a participant and a study partner. Study partners play critical roles for trial success. Yet, little is known about the impact of study partners, especially in trials that enroll individuals with mild cognitive impairment (MCI). At this year’s Clinical Trials on Alzheimer’s Disease (CTAD) conference in Boston, Navneet Hakhu from the Grill/Gillen lab presented data about who study partners are in these important clinical trials. He showed that the prevalence of adult child and other dyads was much lower than that of spousal dyads. But importantly, these adult child and other dyads were much more likely…
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Cognitive assessments are a crucial part of Alzheimer’s disease studies as these help track cognitive decline; however, these assessments may be subject to a practice effect, an improvement in scores due to familiarity with the assessment. Practice effects can mask cognitive decline, so it is important to understand whether these exist in commonly used assessments. At this year’s Clinical Trials on Alzheimer’s Disease (CTAD) conference in Boston, Michelle Nuño in the labs of Drs. Joshua Grill and Daniel Gillen, presented the group’s work investigating whether the letter fluency test, a commonly used assessment, is subject to a practice effect. Through…
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UCI MIND In The News: Dec 3 is International Day of Persons with Disabilities. So congratulations to Dr. Elizabeth Head of University of California, Irvine -- Recognized as an Expertscape World Expert in Intellectual Disability: https://expertscape.com/ex/intellectual+disability
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UCI MIND's podcast, Spotlight on Care, just hit 2,000 downloads! Subscribe today wherever you get your podcasts, and you'll hear our hosts and special guests share stories, experiences, tips, and advice on caring for loved ones affected by Alzheimer's and other dementias. Learn more at mind.uci.edu/podcast
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TODAY is #GivingTuesday – a day that celebrates generosity in all its forms! In honor of this global generosity movement, make a gift today to UCI MIND. We hope you will expand our capacity to conduct promising research and advance progress toward ending Alzheimer’s disease by supporting the UCI MIND Alzheimer’s Disease Excellence Fund. GIVE NOW
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Tomorrow is #GivingTuesday – a day that celebrates generosity in all its forms! In honor of this global generosity movement, consider making a gift today to UCI MIND. We rely on the support of people like you in our community to advance life-changing research and accelerate the fight against Alzheimer’s disease, a devastating illness that impacts more than 6 million Americans and their families. GIVE NOW We hope you will support us by Giving Tuesday, November 30th, 2021 #GivingTuesday
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This month is #NationalCaregiversMonth – a time to recognize and honor family caregivers across California and raise awareness to increase support for caregivers. Many caregivers work and provide care which can make it challenging to maintain their own well-being. . As a caregiver, it’s essential to take care of yourself, too. The California Department of Aging has compiled a list of resources to assist you in this role. https://bit.ly/ALZDcare
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Often people do not realize that they are considered a caregiver, but if you are providing care or assistance to a family member or a friend, YOU are a caregiver. The California Department of Aging has compiled a list of resources to assist you in this role. Whether you are a new or seasoned caregiver, protecting the health and safety of you and your loved ones is always a top priority. https://bit.ly/ALZDcare
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One in five people will develop dementia. Keep your body and brain healthy. Learn more about the facts and figures of Alzheimer’s disease: https://bit.ly/ALZDaware
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One in six baby boomers who live to be 65 years of age and older will develop Alzheimer’s disease. Keep your body and brain healthy. For healthy lifestyle tips and resources, see https://bit.ly/BRAINhealth
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November is Alzheimer's Awareness Month. Alzheimer's disease is the most common form of dementia and causes problems with memory, thinking, and behavior. Alzheimer's disease is not a normal part of aging. Someone with Alzheimer's disease may show signs of: Memory loss that disrupts daily life, such as getting lost in a familiar place or repeating questions. Difficulty completing familiar tasks. Confusion with time or place. Change in mood, personality, or behavior. If you or a loved one shows signs listed above, consult your health care provider. For more information on Alzheimer's disease and dementia, see https://bit.ly/ALZD10
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On Friday September 10th, 2021, UCI MIND and Alzheimer’s Orange County held their annual Southern California Alzheimer’s Disease Research Conference. Due to the COVID-19 pandemic, the event, which was titled “Alzheimer’s From All Angles,” was held virtually on Facebook and YouTube. This year’s conference was moderated by Dr. Joshua Grill and included talks from esteemed experts in the field of Alzheimer’s research. The day kicked off with a presentation from Dr. Sid O’Bryant, Professor of Pharmacology and Neuroscience from the University of North Texas, on the current state of diagnostic blood biomarkers. He explained the process needed to get a blood-based biomarker accepted for use…
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New training grant to attract nation’s brightest scientists UCI MIND’s Drs. Elizabeth Head and Joshua Grill and a core group of faculty members were recently awarded a prestigious National Institute on Aging T32 training grant to help recruit and prepare the next generation of predoctoral and postdoctoral scientists to study Alzheimer’s disease and related dementias. The training grant will support several promising early-stage scientists for a renewable one-year appointment, as they learn from UCI MIND’s renowned faculty. This collaborative opportunity for UC Irvine bridges scientists from the Schools of Medicine, Biological Sciences, Physical Sciences, Information and Computer Sciences, and Social Ecology…
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It has been my privilege to volunteer for UCI MIND’s annual gala planning committee since 2015. The A December to Remember Galas have offered an opportunity for friends of UCI MIND to come together for a festive evening to raise vital support for Alzheimer’s research. This year, facing uncertainty about what the winter months would bring amid the COVID-19 pandemic, and after giving thoughtful consideration for the health and wellbeing of our community and our supporters, UCI MIND has cancelled the 2021 Gala. As you think about your end-of-year giving, please consider making a gift to UCI MIND. It is important to…
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Dr. Elizabeth Chrastil is an Assistant Professor in the Department of Neurobiology and Behavior at UC Irvine.Dr. Chrastil’s lab studies the learning and memory processes related to spatial cognition and navigation.In 2019, she was awarded a UCI MIND / Women’s Alzheimer’s Movement grant to better understand how sex, spatial navigation and Alzheimer’s disease interact. What is spatial navigation? Spatial navigation is the ability to understand where you are on the planet and then how to get to other places. How do you measure a person’s ability to navigate? We use several methods in the lab. For our virtual reality tests,…
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In 2020, Dr. Lindsay Hohsfield, a UC MIND scientist in Dr. Kim Green’s lab studying the role that microglial cells play in Alzheimer’s Disease (AD), started a non-profit organization to provide support to patients and families affected by the early onset inherited form of Alzheimer’s Disease, Autosomal Dominant Alzheimer’s Disease (ADAD), also known as Early Onset Familial Alzheimer’s Disease (EOFAD). Although rare, ADAD is devasting. Dementia-related symptoms begin when people are in their 30s and 40s. Those affected face a unique set of challenges including difficult decisions about genetic screening, family planning, and financial considerations. The genetic nature of the…
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Autosomal Dominant Neurodegenerative Diseases (ADND), like Huntington’s disease and the rare form of inherited early onset Alzheimer’s disease, are particularly challenging brain disorders, in part because they begin to show symptoms when people are mid-career and parenting younger children. ADND are caused by inherited genetic mutations and researchers can test for these mutations at any age, creating an opportunity to test interventions as possible preventative therapies before even the earliest signs of brain changes. Yet, many people who are at risk to inherit these mutations choose not to undergo testing and, while there is critical need for these at-risk individuals to participate in prevention trials, significant scientific and ethical complications are brought to bear…
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While aging is typically associated with cognitive decline, some individuals are able to diverge from the characteristic downward slope and maintain very high levels of cognitive performance. Prior studies have found that cortical thickness in the cingulate cortex, a region involved in information processing, memory, and attention, distinguish those with exceptional cognitive abilities when compared to their cognitively more typical elderly peers. Others major areas outside of the cingulate, such as the prefrontal cortex and insula, are also key in successful aging well into late age, suggesting that structural properties across a wide range of areas may better explain differences…
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A blood test may be able to identify individuals at increased risk for developing Alzheimer’s disease symptoms, according to research presented at the Clinical Trials on Alzheimer’s Disease conference. The results came as part of the AHEAD study. Joshua D. Grill “The goal of this study is to stop Alzheimer’s disease before it begins — delaying or preventing symptoms in people at increased biological risk,” Joshua D. Grill, PhD, recruitment unit co-chair for the Alzheimer’s Clinical Trials Consortium, which helps oversee the AHEAD Study Recruitment and Retention Working Group, told Healio Psychiatry. “The latest advance is to use a blood test to improve the…
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Overall, this nice series of experiments identifies yet another component of the sleep/wake regulatory system—the TRN—that is disrupted by Aβ and degenerated in AD. It is interesting that stimulating the TRN can impact Aβ. It is unlikely, however, that the TRN is the only stimulation target necessary, and that stimulating it would address all the sleep disruptions caused by Aβ and also tau pathology. AD pathophysiology impacts multiple different systems regulating sleep, including brainstem and hypothalamic nuclei, cortical nodes regulating slow wave expression, and even the hippocampus that regulates ripples, and coupling of slow waves, sleep spindles, and ripples. This…
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Message from the Director Dear Friends of UCI MIND, Fall is here and the COVID-19 pandemic is still with us. Though we are seeing signs of improvement, life is not yet back to normal. This fall, the pandemic once again forced us to move several of our major annual activities to a virtual format (page 7) or to cancel them entirely (page 5). But it has not slowed the important work happening at UCI MIND. In this issue, you will learn about funded work from Dr. Liz Chrastil (page 4). She studies the hippocampus, a part of the brain affected…
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Certain antihypertensive medications, particularly diuretics, are linked to lower Alzheimer's disease neuropathology (ADNP) and other brain disease processes, new research shows.
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Drs. Jean Ho (left) and Daniel Nation (right)Photo: Steve Zylius/UCI Continuing all this week, National Public Radio's “Academic Minute” series features a UCI expert. This Friday, tune in to hear Jean K. Ho, postdoctoral scholar at the UCI Institute for Memory Impairments and Neurological Disorders, who studies how hypertension medications help ward off memory loss. Learn More At NPR's Academic Minute: https://www.npr.org/podcasts/564572329/the-academic-minute You Can Also Listen On Apple Podcasts: https://podcasts.apple.com/podcast/1060078714
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Autosomal Dominant Neurodegenerative Diseases (ADND) like Huntington’s disease and the rare form of inherited early onset Alzheimer’s disease are particularly challenging brain disorders, in part because they often begin at an early age. Sarah Hernandez, PhD Lindsay Hohsfield, PhD UCI MIND researchers, Drs. Sarah Hernandez (Thompson Lab) and Lindsay Hohsfield (Green Lab) recently published a perspective article in the Journal of Translational Medicine on the added scientific and ethical issues that should be considered when enrolling participants of child-bearing potential into ADND prevention clinical trials. To better understand their unique perspective on this topic read their paper > To learn…
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Join Neuropsychologist Dr. Michelle McDonnell on Thursday, Oct 21 @ 12 PM PT for a live discussion and Q&A on what to do if you suspect that you have a #memory problem. Bring your questions! See you Thursday on: Facebook YouTube
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The Women's Alzheimer's Movement - WAM spoke to University of California, Irvine’s Dr. Elizabeth Head about her latest research into the link between #Alzheimers and #DownSyndrome. Learn more about her study funded through the UCI MIND WAM Initiative. WAM: Why are we studying Alzheimer’s disease in people with Down syndrome? Is there a link? Dr. Head: Within the Down syndrome population, 95% of people have a full extra copy of chromosome 21. This chromosome contains a gene that is responsible for making the beta-amyloid protein that clumps together to form amyloid plaques in the brain, which is a hallmark of Alzheimer’s…
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Marina Ritchie Congratulations to UC Irvine Neurobiology and Behavior graduate student, Marina Ritchie for receiving the award for Best Virtual Student Poster in the theme of Drug Development at this year’s Alzheimer’s Association International Conference #AAIC2021! Her poster, on "Estimating attrition in mild-to-moderate Alzheimer’s disease and Mild Cognitive Impairment clinical trials," excellently conveyed her research to the judges and attendees at the esteemed conference earlier this year. As a 3rd year graduate student in the labs of Drs. Josh Grill and Daniel Gillen, Marina’s research focuses on identifying means to improve recruitment, retention and overall study design in Alzheimer’s disease…
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(Photo : Image from Unsplash Website) Neuroscientists Find How Associative Memories Are Made Neuroscientists have reportedly found how associative memories are made. The ability to be able to remember relationships that are made between unrelated items like odor and location, songs and events, is known as associative memory. The University of California, Irvine's neuroscientists, have reportedly discovered some specific types of neurons within the brain's memory center that are responsible for acquiring brand new associative memories. The findings of the study were reportedly published in the journal Nature, as also seen in news-medical.net. Psychologists reportedly started studying associative memory as…
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UCI MIND’s Drs. Elizabeth Head and Joshua Grill and a core group of faculty members were recently awarded a prestigious National Institute on Aging T32 training grant to help recruit and prepare the next generation of predoctoral and postdoctoral scientists to study Alzheimer's disease and related dementias. The training grant will support several promising early stage scientists for a renewable one-year appointment, as they learn from UCI MIND’s renowned faculty.
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Message from the Director Dear Friends of UCI MIND, The summer of 2021 brought the Tokyo Olympics of 2020. Our UCI MIND researchers continue to earn gold medals for their work in fighting Alzheimer’s disease and related disorders (page 1). Gold medals also go to Virginia Naeve and Steve O’Leary for establishing a remarkable resource for caregivers, Spotlight on Care (page 4), available through UCI MINDCast. Spotlight on Care is made possible by the generous support of Stephen Hamill and his family (page 5). And our REMIND trainees were also shining stars this summer—launching a new program to inspire local…
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The linked editorial from JAMA Neurology cites IMPACT-AD, the course co-led by UCI MIND, and work by The 90+ Study investigators, Maria Corrada, ScM, ScD and Claudia Kawas, MD. The systematic review by Mooldijk et al1 summarizes multiple areas in which the field of dementia research can improve clinical studies. Our Editorial will focus on ethnic and racial diversity (primarily in the US) and on age differences noted in the systematic review between population-based cohorts and clinical cohorts. We also share new and ongoing efforts in this area from the National Institute on Aging (NIA) and the broader National Institutes of…
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On June 28–29, 2021, the National Academies of Sciences, Engineering, and Medicine held a virtual workshop, “Behavioral and Social Research and Clinical Practice Implications of Biomarkers and Other Preclinical Diagnostics of Alzheimer's Disease (AD) and AD-Related Dementias” (AD/ADRD). UCI MIND Director Joshua Grill was an invited participant in this meeting, for which a brief report is now available.
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Panel of experts from around the nation to give updates on what is the third leading cause of death in Orange County. UCI MIND and Alzheimer’s Orange County will host a free, virtual conference featuring experts discussing the latest developments in research around Alzheimer’s disease, which is Orange County’s third leading cause of death and afflicts more than 84,000 residents. The 32nd annual conference, “Alzheimer’s From All Angles,” will stream live on YouTube and Facebook on Sept. 10 from 8 a.m. to noon. One particularly timely topic will be what effect a viral disease like COVID-19 can have on brain…
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Join Orange County Aging Services Collaborative on Sept 24th from anywhere! This conference is meant for older adults and those who support them. Family, friends, professionals, general public, community, and YOU! RSVP HERE: https://bit.ly/TSIGSept24
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The National Institute on Aging has online health information in Spanish for older adults and caregivers on more than 60 topics related to healthy aging, caregiving, and Alzheimer’s disease and related dementias. https://www.nia.nih.gov/espanol
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