🧠 ASK THE DOC LIVE: Understanding cutting edge spatial technologies🔬 We'll discuss how Dr. Shi uses biochemistry and advanced microscope technology to create maps within brain tissue to better understand the cellular basis of diseases like Alzheimer's and depression. Host: Joshua Grill, PhD, Director of UCI MIND Guest: Xiaoyu Shi, PhD, Associate Professor, Developmental and Cell Biology, Chemistry, BME 🔍 What You'll Discover: How does microscopy lead to new biomarkers for Alzheimer's disease? What is spatial proteomics? LIVE Q&A – Ask your questions in real-time! 📅 Wednesday, March 25th @ 12:00 PM PT 📍 Facebook Live & YouTube Live…

Professor of Health, Society, & Behavior, Leigh Turner, PhD, was recently quoted in Nature regarding the risks and regulatory gaps surrounding stem-cell clinics. Read the full article here.

Celebrating Leadership in Brain Health Equity: Dr. Crystal M. Glover By Lupe Morales This Black History Month, I’m honored to share highlights from the UC Irvine School of Medicine spotlight on Dr. Crystal M. Glover’s research, released earlier this month. Dr. Crystal M. Glover serves as the Leader of the Outreach, Recruitment, and Engagement (ORE) Core at the UC Irvine Institute for Memory Impairments and Neurological Disorders (UCI MIND) and is an Associate Professor of Neurology focused on advancing aging and brain health equity. Her work centers on a simple but powerful belief: everyone deserves the opportunity to age with…

UCI MIND's Dr. Min Zhang has published groundbreaking research in the journal, Alzheimer's & Dementia, revealing a first-of-its-kind genetic map that explores how genes may interact in a human brain with Alzheimer's. This innovative approach opens new pathways to explore other networks involved in Alzheimer's disease-specific pathologies.  To read a summary of the journal article click here: https://www.sciencealert.com/first-of-its-kind-map-of-alzheimers-reveals-hidden-gene-activity

Critical gaps remain for people diagnosed with Alzheimer’s disease disease seeking treatment and care. To address these gaps, Congress has introduced the BRIDGING Relief in Delayed Government Enrollment (BRIDGE) for Young Onset Alzheimer’s Disease Act (H.R. 6799). This legislation could fundamentally change access to care for people diagnosed with Alzheimer’s before age 65.   Today, individuals with young onset (<65 years of age) Alzheimer’s typically face a 29-month wait for Medicare coverage for new amyloid-targeting treatments, after being determined eligible for Social Security Disability Insurance. During that time, the disease progression continues and may render many of these patients no longer…

🧠 ASK THE DOC LIVE: Inside the Brain – Understanding Alzheimer's Pathology 🔬 Ever wondered what Alzheimer's disease actually looks like in the brain? Join us for a fascinating live Q&A that takes you inside the microscope! Host: Joshua Grill, PhD, Director of UCI MIND Guest: Jerry Lou, MD, UCI Neuropathologist 🔍 What You'll Discover: What ADRD pathologies look like under the microscope How brain autopsies confirm Alzheimer's diagnoses The science behind plaques, tangles, and brain changes LIVE Q&A – Ask your questions in real-time! 📅 Wednesday, February 25th @ 12:00 PM PT 📍 Facebook Live & YouTube Live Whether…

The UC Irvine School of Medicine, recently featured Associate Professor of Neurology and UCI MIND’s Outreach, Recruitment, and Engagement Core Leader, Crystal M. Glover, PhD. Dr. Glover is an applied social psychologist, mixed methodologist, and health disparities researcher focused on healthy aging and how structural and social factors impact brain health and dementia. To read Dr. Crystal Glover’s featured spotlight, click here: https://medschool.uci.edu/news/crystal-m-glover-phd-advances-optimal-aging-outcomes

UCI MIND faculty Drs. Ahmad Sajjadi and Joshua Grill explore groundbreaking dementia research featured in AARP, including insights on limbic-predominant age-related TDP-43 encephalopathy (LATE), a condition affecting many in their 80s and 90s , and the future of LATE in field of dementia research. Read the full AARP article: https://www.aarp.org/brandamp/ucirvine-hope-for-families-facing-dementia.html You can make a difference. Learn more, participate in research, or support UCI MIND's mission by clicking the following link: https://mind.uci.edu/uci-mind-press-landing/

Alzheimer’s disease remains one of the most pressing neurological challenges of our time, affecting millions worldwide and unfolding through a complex interplay of amyloid buildup, tau pathology, inflammation, and vascular injury. While much progress has been made in understanding these processes, an important piece of the puzzle—how changes in the brain’s blood vessels contribute to the onset and progression of dementia—remains underexplored. A particularly informative window into this biology comes from people with Down syndrome, who carry a third copy of chromosome 21. Because chromosome 21 includes several genes involved in amyloid production and inflammatory signaling, nearly all adults with…