Commentary on anti-inflammatories for Alzheimer’s prevention

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Contributed by Andrea J. Tenner, PhD Researchers at McGill University recently published results from a clinical trial of the common non-steroidal anti-inflammatory drug (NSAID), naproxen, showing that it was ineffective at preventing Alzheimer’s disease (AD) in cognitively unimpaired people with a family history. I am not surprised by this result, as naproxen is a nonselective inhibitor of inflammatory mediators.  Dr. Breitner, the lead investigator on the manuscript, is an excellent physician scientist.  The study authors indicated that the results do not rule out a benefit from mid-life anti-inflammatory drugs, and that the study turned out to have too few participants…

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Dr. Kim Green Comments on ‘Missing Microglia’ for The Atlantic

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The Atlantic – April 11, 2019.  Kim Green, a neurobiologist at UC Irvine, notes mutant mice lacking microglia have broadly similar patterns of disorganization in their brains. These mice models essentially predicted what would happen in the human. He had just never expected to see a person without microglia. “It’s absolutely remarkable,” he says.

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Does Red Wine Really Help You Live Longer? Dr. Claudia Kawas Comments for TIME

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TIME – April 11, 2019. “Alcohol could be beneficial through biological mechanisms like increasing [healthy] HDL cholesterol, affecting clotting mechanisms and blood platelets, or [having] effects on the vascular system,” says Dr. Claudia Kawas, a professor of neurology at the University of California, Irvine whose research has found that some of the oldest-living adults tend to drink alcohol in moderation.

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Big IDEAS May Improve Clinical Management of Dementia

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Contributed by S. Ahmad Sajjadi, MD, PhD, Neurologist Last week, the results of a very important and highly anticipated study, the IDEAS (Imaging Dementia – Evidence For Amyloid Scanning) study, were published in the Journal of the American Medical Association (JAMA). This national multi-center study, including UC Irvine, enrolled more than 11,000 Medicare beneficiaries with cognitive impairment to undergo a special type of scan called amyloid positron emission tomography (PET). Amyloid PET scan provides the opportunity to visualize the accumulation of abnormal amyloid plaques on the brain. Amyloid and tau proteins are the hallmarks of Alzheimer’s disease (AD). The study…

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Dr. Joshua Grill Discusses ‘Pseudomedicine’ with AARP

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AARP – April 10, 2019. “A common situation is an older adult becoming concerned about their memory and taking a supplement to try to ward off dementia,” says Joshua Grill, director of the Institute for Memory Impairments and Neurological Disorders at the University of California, Irvine. “But in reality, if they saw their doctor, they might find out that another medical condition such as hypothyroidism, or a certain prescription medication, is causing symptoms and can be easily treated. They’re just making things worse.” And if you do have dementia, he adds, you could start a drug treatment to relieve symptoms,…

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