First-of-its-kind study links the sleeping brain to toxin-clearing

By | Commentary, In the News

Contributed by Bryce Mander, PhD A new landmark study from researchers in Boston was published in Science this month. This study linked human brain waves during deep sleep, called “slow waves,” with the pulsating flow of cerebrospinal fluid (CSF) through the brain.   This study is important because it is the first to directly link sleeping brain waves with a mechanism thought to clear the brain of metabolic waste and toxins, called the “glymphatic system.” Prior studies in rodents indicate that the glymphatic system actively clears Alzheimer’s disease pathology, as well as other toxins and waste products, from the brain….

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Another hopeful outcome for Alzheimer’s treatment

By | Commentary, In the News

Contributed by David Sultzer, MD, Professor of Psychiatry & Human Behavior This past weekend, China’s regulatory agency conditionally approved sodium oligomannate for the treatment of mild to moderate Alzheimer’s disease.  The approval was based on results from a 9-month treatment study of 818 people, and is the first approval globally of an Alzheimer’s drug in 16 years. Oligomannate (GV-971) is a plant-based complex sugar derived from ocean seaweed. It’s thought to adjust the microbiome in the GI tract, thereby tweaking amino acid levels in the body and reducing the toxic effects of brain inflammation that contribute to Alzheimer’s disease.  Results from…

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Will I get Alzheimer’s if I live long enough?

By | Community Events

Tune in this Friday, November 1 @ 9AM for the next episode of our monthly Facebook LIVE series, “Will I get Alzheimer’s if I live long enough?” This month, we’re joined by Maria Corrada, ScM, ScD, Professor of Neurology and Epidemiology in the UCI School of Medicine. Dr. Corrada received a masters in Biostatistics and a doctorate in Epidemiology from Johns Hopkins University. She currently serves as co-principal investigator of The 90+ Study, a longitudinal study of aging and dementia in over 1,800 people aged 90 years and older, and Life After 90, a multiethnic cohort of people 90 and older in Northern California. Dr. Corrada’s research focuses…

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