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New genetically modified mouse model mimics multiple aspects of human Alzheimer’s disease

By Carousel Slider, Commentary, In the News

NIA-supported scientists have developed a new mouse model that produces a form of the human beta-amyloid protein, a hallmark of Alzheimer’s disease. An important research tool, mouse models enable the exploration of genetic, environmental, and behavioral aspects of Alzheimer’s, as well as make it possible to test drug candidates before human studies. The new mouse model, which was reported in a recent article in Nature Communications, can be used by other scientists to advance Alzheimer’s research. Model Organism Development and Evaluation for Late-Onset Alzheimer’s Disease (MODEL-AD) MODEL-AD consortium Many factors, including gene changes, the aging process, and conditions in the…

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María M. Corrada, ScM, ScD at AAIC 2021

By Commentary, Community Events, In the News

Related posts: 5TH ANNUAL HUNTINGTON’S DISEASE EDUCATIONAL SYMPOSIUM 5TH ANNUAL HUNTINGTON’S DISEASE EDUCATIONAL SYMPOSIUM SATURDAY, OCTOBER 3rd, 2020, 1:00 – 3:00 PM   Join us for the 2020 Huntington’s Disease Educational Symposium! Due to health concerns over the current COVID-19 pandemic, this year we will be hosting a “virtual” educational symposium. There is no cost to participate, but you must… Sex differences in hallmarks of Alzheimer’s disease: new study finds faster tau accumulation in female brains Contributed by Ashley A. Keiser, PhD A new study from researchers in Sweden published in Brain finds faster accumulation of a major hallmark of Alzheimer’s disease, neurofibrillary…

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UCI MIND Director speaks on AAIC panel about impact and ethics of Aduhelm approval

By Commentary, In the News

Related posts: 5TH ANNUAL HUNTINGTON’S DISEASE EDUCATIONAL SYMPOSIUM 5TH ANNUAL HUNTINGTON’S DISEASE EDUCATIONAL SYMPOSIUM SATURDAY, OCTOBER 3rd, 2020, 1:00 – 3:00 PM   Join us for the 2020 Huntington’s Disease Educational Symposium! Due to health concerns over the current COVID-19 pandemic, this year we will be hosting a “virtual” educational symposium. There is no cost to participate, but you must… New Mouse Model Provides 1st Platform to Study Late-Onset Alzheimer’s UCI School of Biological Sciences Dean Frank LaFerla is co-senior author of a study involving a new genetically engineered mouse model that, unlike its predecessors, is based on the most common form of…

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David Sultzer, MD & others show clinical benefit of pimavanserin in AD

By Carousel Slider, Commentary, In the News

UCI MIND professor, David Sultzer, MD, and other investigators show a clinical benefit of an investigational antipsychotic drug, pimavanserin in reducing behavioral symptoms related to Alzheimer’s disease. Related posts: A crucial, overlooked question on the new Alzheimer’s drug: When should patients stop taking it? A crucial, overlooked question on the new Alzheimer’s drug: When should patients stop taking it? STAT News – June 24, 2021 “When we enroll families in studies of treatments like aducanumab, we try to educate them that they should not expect large improvements in cognition or function,” Joshua Grill, director…

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Dr. Vivek Swarup featured on ALZFORUM

By Commentary, In the News

UCI MIND researcher, Dr. Vivek Swarup is gaining significant attention for his work on glial cell gene expression in AD. His lab’s research, published in Nature Genetics 2 weeks ago was recently featured on the heavily trafficked Alzheimer’s research website, Alzforum.com – a testament to the impact his research has on the broader AD community. Dr. Swarup used prefrontal cortex brain tissue from UCI ADRC brain donors to examine differences in glial cell gene transcription between healthy and AD brains.   He found that the areas in the DNA above important AD risk genes, responsible for expressing those genes, were different…

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Sept. 10th Virtual Alzheimer’s Research Conference #AlzAngles: Thomas Lane, PhD

By Commentary, Community Events

Sept. 10th Virtual Alzheimer’s Research Conference #AlzAngles: Dr. Thomas Lane will discuss the impact of viral infections, like COVID-19, on Alzheimer’s disease. Register for free: https://conference.mind.uci.edu/register Related posts: CARE Brain Trust Meeting Contributed by the CARE Registry: It’s time for our very first annual CARE Brain Trust meeting! This is a special meeting for researchers and community partners who want to learn more about the CARE project. We will discuss everything from the importance of representation and our data access protocol! Come… UCI MIND presents Meet the Team UCI MIND presents Meet The Team, a video series where diverse staff…

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Aducanumab update

By Carousel Slider, Commentary, In the News

Contributed by Joshua Grill, PhD and Jason Karlawish, MD UCI MIND Director Joshua Grill, PhD co-authored an article in Nature Reviews Neurology about the FDA’s decision on Aduhelm. Read more on this below: Since the FDA approved Aduhelm (aducanumab) on June 7, there has been considerable conversation, debate, and even backlash about the decision. It may seem difficult to keep up. Here is a recap of some of the most recent important events. The FDA granted Aduhelm what is known as “accelerated approval.” This means that the approval did not indicate that the drug has been adequately shown to benefit…

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New Mouse Model Provides 1st Platform to Study Late-Onset Alzheimer’s

By Carousel Slider, Commentary, In the News

UCI School of Biological Sciences Dean Frank LaFerla is co-senior author of a study involving a new genetically engineered mouse model that, unlike its predecessors, is based on the most common form of Alzheimer’s disease. This could help lead to major strides in the fight to end this deadly disease! Dean LaFerla discusses his findings in a new podcast: https://www.bio.uci.edu/frank-laferla-podcast/ Related posts: FLASH radiation therapy can help treat cancer without neurocognitive side effects, study finds FLASH radiation therapy, also called FLASH-RT, can eliminate the debilitating side effects associated with traditional radiation therapy by delivering the same dose in tenths of…

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Swarup Lab research published in Nature Genetics

By Carousel Slider, Commentary, In the News

Contributed by Vivek Swarup, PhD The brain is made up of billions of cells that are tightly coordinated in complex neural circuitry and are ultimately responsible for manifesting our memories, emotions, and personalities: the very essence of being human. Alzheimer’s Disease (AD) is one of the most prevalent neurodegenerative disorders worldwide and results in cognitive decline and memory loss, and we presently do not have effective treatments for AD. There is a pressing need to deepen our understanding of AD, and by studying how individual cells are changing in disease, or identifying those that are resilient to such changes, we…

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UCI student selected for prestigious research program

By Commentary, In the News

Leslie Vazquez-Rangel, a fourth-year undergraduate at UCI was recently selected to participate in the prestigious Minority Access to Research Careers (MARC) Program, an NIH funded training grant that is awarded to only 640 students across the US each year. The program will allow a select few PhD-bound honors students like Leslie to engage in meaningful research under the guidance of world-renowned professors.  Leslie will spend the next year working with Dr. Elizabeth Head, a professor in the Department of Pathology to study the link between Down syndrome and Alzheimer’s disease. To learn more about Leslie and the incredible research being done in Dr. Head’s lab, visit https://sites.mind.uci.edu/headlab…

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