UCI MIND awarded $14.4 million Alzheimer’s research grant

By Carousel Slider, Commentary, In the News

National Institutes of Health grant helps local researchers continue work on cause and treatment of dementia. The National Institutes of Health has awarded $14.4 million to the UCI MIND institute at UC Irvine to continue its crucial work in the study of Alzheimer’s disease, for which there remains no cure or prevention. UCI MIND, formally known as the Institute for Memory Impairments and Neurological Disorders, is one of only 32 Alzheimer’s Disease Research Centers around the country funded by the National Institute on Aging, an arm of the NIH. UC Irvine is one of the original half-dozen research centers established…

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Facebook LIVE Q&A: How Does Exercise (Or Lack Thereof) Impact The Brain?

By Commentary, Community Events

About the Speaker: Nicole Berchtold, PhD is an associate project scientist at UCI MIND.  She completed her BS in Biology at Duke University, spent 2 years  in neuroscience research at the University of Lausanne in Switzerland, and completed her PhD and postdoctoral research at UCI.  She has over 40 publications investigating biological mechanisms by which exercise enhances hippocampal function and learning, and the molecular changes that occur in the brain with aging and Alzheimer’s disease.  She has helped procure multiple grants for over 25 years and is a regular contributor to journal reviews and conferences in her discipline. Related posts: How are brain scans improving our understanding of…

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Exercise and Brain Health: Facebook LIVE Video Q&A Tomorrow

By Commentary, Community Events

Join UCI MIND on Friday, July 10 at 11:00-11:30 AM for our monthly Facebook Live Q&A series. In this episode, Dr. Nicole Berchtold, a UCI MIND laboratory scientist, will answer your questions about exercise and brain health. Click this direct link to watch the video and ask your questions. Related posts: How are brain scans improving our understanding of Alzheimer’s disease? How are brain scans improving our understanding of Alzheimer’s disease? October 25th Research Conference #SpeakerSpotlight: Dr. William Jagust is a Professor of Public Health and Neuroscience at UC Berkeley and heads the national Alzheimer’s Disease Neuroimaging Initiative’s (ADNI) Core…

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Biogen and Eisai submit aducanumab for FDA approval

By Commentary, In the News

Contributed by Joshua Grill, PhD, Director of UCI MIND This morning (July 8, 2020), Biogen and Eisai announced that the two companies had together completed submission to the FDA for regulatory and marketing approval of aducanumab, the monoclonal antibody against the beta amyloid protein that accumulates in the brain of people with Alzheimer’s disease. We’ve previously written about the unique set of circumstances under which Biogen is submitting their application. Two large Phase 3 clinical trials were halted for futility in 2019, only for later assessments of the study data to lead to the sponsors to conclude that the drug…

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Alzheimer’s biomarkers in Down syndrome parallel late-onset disease

By Carousel Slider, Commentary, In the News

  In an accompanying editorial, [UCI MIND Professor] Elizabeth Head, PhD, of University of California Irvine, and Beau Ances, MD, PhD, of Washington University St Louis, wrote, “Fortea and colleagues noted similarities between biomarkers reflecting Alzheimer disease pathogenesis in individuals with Down syndrome and individuals with late onset and autosomal dominant Alzheimer disease. These results provide strong evidence that studies of people with Down syndrome can inform research on late-onset and autosomal dominant Alzheimer disease.” Read more here > Related posts: UCI develops humanized mice to study human brain cells’ role in Alzheimer’s disease … Revived UCI Sleep Center Focuses on Mental…

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Neighborhood poverty and Alzheimer’s disease

By Commentary

Contributed by Christian Salazar, PhD, UCI MIND Project Scientist While the link between poverty and disease is well documented in health disparities research, a practical way to connect poverty with biological processes has proven to be difficult. Nevertheless, recent advancements like the new publicly-available tool called “The Neighborhood Atlas” has made it easier for health disparities researchers to rank and geographically map neighborhoods according to socioeconomic disadvantage. In a recent JAMA article, researchers linked The Neighborhood Atlas with repositories of brain tissue in a sample of 447 decedents from California and Wisconsin. They found that brain samples from decedents who…

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Breaking News from CA Governor Newsom, and UCI In The News about COVID-19

By COVID-19, In the News

Breaking News from CA Governor Newsom:     COVID-19 cases are spreading at alarming rates in some CA counties. Effective immediately, California Department of Public Health is requiring counties that have been on the County Monitoring List for at least 3 days to move certain sectors outdoors or close. In addition, all brewpubs, breweries, bars, and pubs in these counties must close immediately, both indoor and outdoor. Visit covid19.ca.gov for more information.   UCI In The News: State puts Orange County on coronavirus watch list: Orange County Register: Bernadette Boden-Albala, dean of University of California, Irvine’s public health program and…

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Updated OC Health Officer Orders & Recommendations as of Jul 1

By COVID-19, In the News

AMENDED ORDERS AND STRONG RECOMMENDATIONS OF THE COUNTY OF ORANGE HEALTH OFFICER REVISED July 1, 2020 In light of the recent increased COVID-19 hospitalization rate in Orange County, the placement of Orange County on the California Department of Public Health (CDPH) County Monitoring List, and further CDPH guidance, these AMENDED ORDERS AND STRONG RECOMMENDATIONS revise the prior AMENDED ORDERS AND STRONG RECOMMENDATIONS, issued by the Orange County Acting Health Officer on June 19, 2020.  The June 19, 2020 Amended Orders and Strong Recommendations are no longer in effect as of the effective date and time of these AMENDED ORDERS AND…

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Two sisters wanted to lift lonely seniors’ spirits. Here’s what happened next

By COVID-19, In the News

Shreya and Saffron Patel usually FaceTime their grandparents in England every weekend, but during the novel coronavirus pandemic, they have typically reached out each day. Their grandmother on their mom’s side hasn’t left her apartment in nearly four months. She lives alone and can no longer socialize at the gym. Some of her younger friends have stopped by, and she leans out her kitchen window to chat. One friend sends handwritten letters. When the Patel sisters, who live in Boston, spoke to their grandmother, they noticed her mood improve. She texted them about the cards and showed them to her…

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