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CMS Released Final Decision on Aduhelm

By Commentary, In the News

Contributed by Joshua Grill, PhD: The Centers for Medicaid and Medicare Services (CMS) recently released their final decision related to coverage for the monoclonal antibody against beta amyloid, aducanumab (Aduhelm®). The decision was expected by many and includes only a few changes from the preliminary decision announced January 11. The decision remains that CMS will pay for aducanumab under a coverage with evidence determination (CED). This means that the drug will only be covered when a person with Mild Cognitive Impairment or mild dementia is enrolled in a randomized controlled trial. Such trials will need to be approved by CMS…

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For people with Down syndrome, a longer life, but under a cloud

By Carousel Slider, Commentary, In the News

The Washington Post – April 7, 2022 The FDA approval of Aduhelm ignited a raging debate, with many doctors saying they would not prescribe the drug and several insurers declining to pay for it. Yet even with the uncertainty surrounding the drug, said Elizabeth Head, [professor of pathology], at the University of California, Irvine, it is understandable why some families, especially those in which a loved one with Down syndrome faces an all but certain fate, “might believe doing something is better than doing nothing.” Related posts: New Mouse Model Provides 1st Platform to Study Late-Onset Alzheimer’s UCI School of Biological…

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Study links early life adversity, microglia dysfunction, to aberrant adult stress responses, mental illness

By Carousel Slider, Commentary, In the News

“Much of neuroscience and study of brain diseases has focused on the brain’s neurons. This study highlights that in addition to neurons, other brain cells, and especially immune cells, play crucial roles in brain health and disease,” said Tallie Z. Baram, distinguished professor in the Departments of Anatomy & Neurobiology, Pediatrics, Neurology, and Physiology & Biophysics at the UCI School of Medicine. “Neuroimmune interactions are a novel, important avenue to understanding and treating several brain disorders and mental illness and have been linked by other UCI researchers to Alzheimer’s disease.” Related posts: Aducanumab update Contributed by Joshua Grill, PhD and…

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‘First person’ interview with Gianna Fote in the Journal of Cell Science

By Carousel Slider, Commentary, In the News

First author Gianna Fote was recently interviewed by the Journal of Cell Science for a newly-published paper. She provided commentary on her team’s new findings for UCI MIND: “In our recently published work we studied intracellular trafficking of Apolipoprotein E (APOE), a lipid-carrying protein. The APOE4 isoform of this protein is the biggest genetic risk factor for late-onset Alzheimer’s disease. We found that that APOE can be degraded by a process called autophagy, a process in which cellular waste is transported to an acidic organelle called the lysosome. The APOE4 isoform accumulates in the lysosome and causes increased induction of…

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‘Anyone can get Alzheimer’s. Anyone can be a caregiver.’

By Commentary, In the News

Study reaching caregivers in underserved communities for education, coaching Associate Professor Jung-Ah Lee (right) and her caregiver study team. Caregiving is often called the invisible profession. It isn’t to Jung-Ah Lee. The associate professor at the Sue & Bill Gross School of Nursing has witnessed the burden caregivers carry, especially those caring for a loved one who has dementia. She has dedicated her career to alleviating it. With the help of a research team including community education specialists, also known as community health workers, Lee ensures that important culturally appropriate information about caregiving for someone with dementia reaches those who…

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World Down Syndrome Day 2022

By Commentary, Community Events, In the News

The Head lab celebrating World Down Syndrome Day with their crazy socks! Some of those featured include: Liz Head Lorena Sordo Elizabeth Andrews Jeremy Rouanet Cherie Lepe Lisi Flores-Aguilar Jesse Pascual Learn more about Down syndrome and Alzheimer’s disease at https://sites.mind.uci.edu/headlab Related posts: MIND Matters | Quarterly Newsletter | Summer 2021 Message from the Director Dear Friends of UCI MIND, The summer of 2021 brought the Tokyo Olympics of 2020. Our UCI MIND researchers continue to earn gold medals for their work in fighting Alzheimer’s disease and related disorders (page 1). Gold medals also go to Virginia Naeve and Steve…

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MIND Matters | Quarterly Newsletter | Winter 2022

By Commentary, Community Events, COVID-19, In the News, Participants

Message from the Director Dear Friends of UCI MIND, The COVID-19 surge caused by the Omicron variant has produced unwanted challenges for our research. Yet, our investigators remain unrelenting and highly successful in their work. Dr. Ira Lott received the international Trisomy 21 Research Society Montserrat Trueta Award (page 1). Dr. Claudia Kawas received the UCI Senate Better World Award (page 5). We honored Bob and Virginia Naeve with our UCI MIND Award, though we were unable to hold our A December to Remember Gala, to deliver it with the pomp and circumstance they deserve (page 7). Cherry Justice has…

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New Preventive Vaccine for Alzheimer’s Disease Gets Grant

By Carousel Slider, Commentary, In the News

eturbonews: The Institute for Molecular Medicine (IMM), a non-profit organization dedicated to basic and translational molecular research to develop safe, effective vaccines against #Alzheimers disease and other #neurodegenerative disorders, today announced that it was awarded a $12 million grant from the National Institute on Aging (NIA) division of the U.S. National Institutes of Health (NIH)​ to support clinical trials of its beta-#amyloid (Aβ) vaccines based on DNA (AV-1959D) and recombinant protein (AV-1959R) for the prevention of Alzheimer’s disease (AD). In collaboration with the @ucirvine (Principal Investigator, David Sultzer, M.D.) and @uscedu (Principal Investigator, Lon Schneider, M.D.), IMM (Principal Investigator and…

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Frequent and Feared. But Can Dementia Be Avoided?

By Carousel Slider, Commentary, In the News

Managed Healthcare Executive – March 17, 2022 According to the CDC, about 5 million Americans have Alzheimer’s disease …. “These numbers are projected to increase because elderly individuals are the fastest-growing segment in the United States,” says Claudia H. Kawas, M.D., a professor in the Department of Neurology at the University of California, Irvine, School of Medicine. … The things known about dementia risk that are potentially modifiable are all related to general health and maintenance of health, says Kawas, noting the association between control of high blood pressure and cholesterol levels and a lower risk of dementia. Related posts:…

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Dr. Josh Grill Giving A Talk in English with Mandarin Chinese Translation 3/24/22

By Commentary, Community Events, In the News

UCI MIND Director Dr. Josh Grill is giving a talk on Zoom about Dementia Care, hosted by Happy 50 Plus, on March 24, 2022 from 4-5:30 PM. He will be speaking on “Effective Diagnosis and Treatment for Alzheimer’s, and What’s New on the Horizon.” This event will be in English with Mandarin Chinese translation. The talk is free to join, but pre-registration is required. Zoom Registration link: bit.ly/DementiaCare0324 Please see the flyer below for information regarding this upcoming event. Related posts: UCI MIND graduate student Marina Ritchie Awarded Best Virtual Student Poster at AAIC 2021 Congratulations to UC Irvine Neurobiology…

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