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Commentary

Dr. Joshua Grill discusses A4 Study results in Alzforum

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This week Alzforum posted coverage from the Alzheimer’s Association International Conference, including UCI MIND Director Dr. Joshua Grill’s presentation of data from The A4 Study (Anti-Amyloid Treatment in Asymptomatic Alzheimer’s Disease Study). In The A4 Study, a secondary prevention trial of late-onset Alzheimer’s disease, people with elevated amyloid had higher levels of memory complaints than those without elevated amyloid. To read the full article, click here > 

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The impact on everybody else, it’s enormous

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Contributed by Joshua Grill, PhD This week’s 60 Minutes did an excellent job of illustrating, in 13 minutes, the 10-year progression of Alzheimer’s disease and its impact on patients and their caregivers. In addition to the unrelenting progression of the disease, the piece showed viewers the toll the disease takes on care providers, including the physical, financial, and emotional burdens. On average, the cost of caring for a person with Alzheimer’s disease is estimated to exceed $300,000 total. And caregivers are at increased risk for physical and mental ailments, resulting from the stress of their role and the fact that…

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New York Times article breaks down barriers to recruitment and brings hope with a new trial

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The New York Times recently covered a new clinical trial effort Eli Lilly is undertaking, the TRAILBLAZER-ALZ clinical research study. The study, which UCI MIND investigators are participating in, aims to enroll 375 people with early Alzheimer’s disease. To learn more about the TRAILBLAZER-ALZ study, click here, or contact us at research@mind.uci.edu or call 949.824.0008.

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UCI Researchers awarded grant to explore gender differences in Alzheimer’s

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Currently, 2 out of every 3 people with Alzheimer’s disease are women. Last year, UCI MIND began a partnership with Maria Shriver’s Women’s Alzheimer’s Movement. This partnership launched a grant competition focused on understanding the role of sex in Alzheimer’s disease. UCI researchers Sunil Gandhi and Mathew Blurton-Jones have been awarded this year’s $100,000 grant. Their research will focus on the role of microglia in the brains of men and women using induced pluripotent stem cells generated from skin cells donated by UCI ADRC participants, modern mouse models of the disease, and cutting edge microscopy techniques. To learn more >

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We’re happy to hear good news, but we still need to see the data

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This week, BioArctic Neuroscience, Esai, and Biogen made headlines when they announced via press release the topline and positive results of their Phase 2a study of the anti-amyloid antibody BAN2401. The press release indicated that the drug “demonstrated statistically significant slowing in clinical decline and reduction of amyloid beta accumulated in the brain” in patients with early Alzheimer’s disease. To be sure, this is welcomed news. Too often headlines for Alzheimer’s disease clinical trials are about “flops” and “failures.” So we should take this good news and embrace it. Unfortunately, there remain many questions to which we need answers before we…

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With Mother’s Day in MIND

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Reflections on Mother’s Day by Virginia Naeve and Dr. Rosalyn Laudati, members of the UCI MIND Leadership Council. I just received an email advertisement from a lovely seaside restaurant stating that they are providing a “Mother’s Day Brunch that your mother will never forget.” I would have loved taking mom there on Mother’s Day, but Alzheimer’s disease forever changed those kinds of plans for us. Up until about the last four years of mom’s disease, we always loved Mother’s Day. Unfortunately, as her disease progressed, it was heartbreaking for me to realize that Mother’s Day had lost its meaning for…

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