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Commentary

The Real Deal on Brain Health Supplements

By | Commentary, In the News

The Global Council on Brain Health (GCBH), in partnership with AARP, recently released an extensive report reviewing the current evidence on brain health supplements. AARP formed the GCBH by bringing together an independent group of scientists, physicians, researchers, and other experts. Click here to learn more about these specialists. The GCBH found that there was a lack of evidence for effectiveness, concerns about false claims in marketing, and uncertainty of the possible risks of brain health supplements, since they are not required to be reviewed for purity, safety, and efficacy. The GCBH concluded that no endorsement could be made for…

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Alzheimer’s prevention clinical trial discontinued

By | Commentary, In the News

Contributed by Joshua Grill, PhD The field of Alzheimer’s disease drug development received more troubling news yesterday, when the leaders of the GENERATION program halted their prevention clinical trials of a drug aiming to prevent the formation of the beta amyloid protein in people at risk to get Alzheimer’s disease. The GENERATION program is led by investigators at Banner Alzheimer’s Institute and is an important study in people at increased genetic risk to someday develop Alzheimer’s disease, based on the apolipoprotein E (APOE) gene. The trials were stopped because preliminary results indicated that the drug under study, CNP520 (being developed…

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The Impact of Alzheimer’s Disease on the Workplace

By | Commentary, In the News

Contributed by Joshua Grill, PhD, Director of UCI MIND A recent report from The Economist concludes that three neurological disorders — migraine, multiple sclerosis, and Alzheimer’s disease — are impacting workplace productivity. Notably, all three conditions disproportionately affect women. While it is now clear that Alzheimer’s disease begins decades prior to diagnosis, the larger impact on the global economy results from the growing number of workers who are trying to balance employment as well as caregiving for a parent with the disease. More than 16 million Americans are unpaid caregivers for someone with Alzheimer’s disease and the most common caregiver is…

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UCI MIND scientists discover exercise can reprogram genes

By | Carousel Slider, Commentary, In the News

Contributed by Carl W. Cotman, PhD and Nicole C. Berchtold, PhD It is increasingly recognized that exercise builds brain health. At a fundamental level, brain health and function depend on the expression of the brain’s genes, the building blocks of cells. In a recent paper that appeared in the journal “Neurobiology of Aging” (2019), Drs. Carl Cotman, Nicole Berchtold and coworkers demonstrated that in the brains of healthy older people, exercise reprograms gene expression patterns to a more youthful state, even in cognitively normal people (75-100 yrs old). Genes that were particularly targeted are those that boost cellular energy production and build…

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