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In the News

Yes! A positive Phase 3 treatment study for symptoms of dementia

By | Commentary, In the News

Contributed by David Sultzer, MD, Professor of Psychiatry & Human Behavior Last week, Acadia Pharmaceuticals announced findings from its trial of pimavanserin for treatment of delusions and hallucinations related to dementia: Participants treated with pimavanserin had better outcomes than those treated with placebo. The study design was different from usual treatment comparisons of drug and placebo.  In this trial, all participants with psychosis symptoms along with Alzheimer’s disease or another cognitive disorder were treated with pimavanserin for 12 weeks.  Those who showed improvement were then assigned to either continue taking the drug or cross over to placebo treatment.  The study…

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Another setback, yet another reason to redouble our efforts

By | In the News

Contributed by Joshua Grill, PhD, Director of UCI MIND Late Thursday evening, Esai publicly announced a decision to halt a Phase 3 clinical trial of a candidate treatment for Alzheimer’s disease, elenebecestat. The decision was made based on a recommendation by the study’s Data Safety Monitoring Board, which determined that the safety risks of the drug no longer justified continuing the study. Elenebecestat is a BACE (beta-site of the amyloid precursor protein cleavage enzyme) inhibitor that joins several other BACE inhibitors previously determined to lack adequate safety for patient use. The field will grapple with this news and learn how…

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Summer 2019 MIND Matters Newsletter

By | Commentary, Community Events, In the News

In this issue of MIND Matters: UCI MIND Scientists Discover Exercise Can Reprogram Genes Welcome, New Faculty & Staff New FDA Black Box Warning for Insomnia Medications Announcing the 10th Annual UCI MIND Gala Honorees… And more! Download Newsletter >   Upcoming Events:   Facebook LIVE Q&A Series: “What have researchers learned from brain donations?” Friday, September 6  |  9:00-9:30 am |  UCI MIND Facebook Page Follow @UCIrvineMIND to receive notifications when we go LIVE Live online Q&A with Edwin Monuki, MD, PhD, Professor and Warren L. Bostick Chair of Pathology in the UCI School of Medicine.  Attend the video live on our Facebook page or view archived…

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Commentary on the link between brain disease and sleep-wake systems

By | Commentary, In the News

Contributed by Bryce Mander, PhD Our colleagues at UCSF recently published findings in the journal Alzheimer’s and Dementia examining how tau pathology in different brain diseases – Alzheimer’s disease, progressive supranuclear palsy, and corticobasal degeneration – impacts brain cells that are in charge of keeping us awake. This study reported several important findings: In all three diseases, there was a reduction in brain cells that help promote cortical arousal. In all three diseases, tau pathology was quite substantial in several of the wake-promoting cells in the brainstem region. Tau pathology in the brainstem in Alzheimer’s disease was associated with a much…

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