"As part of HFC's Science Advisory Board, I will continue our great work in pairing students and faculty to research brain aging and Alzheimer’s disease. Excited for all that is to come from the partnership between HFC and UCI MIND!” - Joshua Grill, Director of UCI MIND To read more about our new program, in partnership with the nonprofit HFC led by Lauren & Seth Rogen, community philanthropist Dr. Loran Carlin, and the UCI School of Medicine, click here >
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A recent report from Stanford identified the top 2% of the world's scientists based on their publications and citations. Out of millions of published scientists, including those who have passed away, a total of 445 from UCI, including Vice Chancellor for Research Pramod Khargonekar, and 18 UCI MIND faculty made the cut. We congratulate our faculty members, listed below, on this significant achievement: Neurology & Neurosurgery: Tallie Z. Baram, MD, PhD Ruth Benca, MD, PhD Emiliana Borrelli, PhD Gregory J. Brewer, PhD Carl W. Cotman, PhD David Cribbs, PhD Mark J. Fisher, MD Christine Gall, PhD Charles Glabe, PhD Alan…
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Contributed by Hal S. Stern, PhD and Frank M. LaFerla, PhD It is our pleasure to congratulate Charles Glabe, Distinguished Professor of Molecular Biology and Biochemistry, on being named a 2020 fellow of the National Academy of Inventors. Among his achievements, Professor Glabe is being recognized for the creation of antibodies that bind to the four kinds of proteins forming the amyloid associated with Alzheimer's disease. The process enables scientists to detect individual forms of the disease more precisely. The antibodies can be used as a screening tool and could help develop immunotherapies that slow or even prevent Alzheimer's. Professor…
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Tomorrow A December to Remember Gala, presented by UCI MIND and the Harris Taylor Family, is tomorrow! We look forward to an evening of music, magic, and memories for Alzheimer's research. Pre-Show at 5:30 PM PST Live Program at 6:00 - 7:00 PM PST Three Viewing Options: YouTube Live (watch on your Smart TV) Facebook Live (interact with other viewers) Gala Website (quick access to auction items) Live Stream Link Silent Auction The gala auction is now live and closes Monday, December 7 at 12:00 PM PST. Two Ways to Bid: Visit mind.uci.edu/bid Text MIND to 61094 View Auction Presenting Sponsor Harris…
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Getty Images MarketWatch - Nov. 30, 2020 The University of California, Irvine’s Institute for Memory Impairments and Neurological Disorders (UCI MIND) has studied elderly individuals as part of its “90+ Study” since 2003, analyzing the ways in which nearly 2,000 participants go about their lives in their 90s and 100s, as well as what may have contributed to that longevity and underlying cognitive disabilities they may or may not know they have. … Half of children born this decade can expect to see their 103rd or 104th birthday, Claudia Kawas, co-principal investigator of The 90+ Study, told CBS. Read more >
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Alzheimer’s Biomarker Consortium – Down Syndrome (ABC-DS) Award The University of California, Irvine is undertaking a five-year, multi-million dollar project to expand research on Alzheimer’s disease in people with Down syndrome. The National Institute of Health awarded a $109 million grant to the Alzheimer’s Biomarkers Consortium-Down Syndrome in late October. The international team, led by UCI principal investigators Elizabeth Head and Mark Mapstone, aims to identify biomarkers that indicate the progression of Alzheimer’s disease in adults with Down syndrome. Subscribers to the Orange County Business Journal can read more here >
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Dear friends of UCI MIND, Last week, Maria Shriver and the Governor's Task Force on Alzheimer's Prevention and Preparedness presented a report describing their 10 recommendations to Governor Gavin Newsom. Click here to view the report. The Governor was extremely receptive to the recommendations. We anticipate movement in the coming months to years on these important initiatives to improve the lives of Californians living with dementia and their families and to increase Alzheimer’s awareness, risk reduction education, and research. We would like to thank the many UCI MIND stakeholders who participated in the Task Force listening session as part of…
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Will Biogen’s aducanumab become the first drug approved to slow progression of Alzheimer’s disease? UCI MIND faculty member and chair of UCI Statistics, Dr. Daniel Gillen, and other experts comment on ALZFORUM.
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CBS: Six years after our initial report, Lesley Stahl visits surviving members of the 90+ Study and finds out what scientists have learned from following the study's participants. We're a nation living longer and longer. Over the next 30 years, the number of Americans age 90 and above is expected to triple, and an NIH-funded research study called 90+ at the University of California Irvine is trying to learn all it can right now from a group of men and women who've already managed to get there. Six years ago, we first reported on their first set of findings. Factors…
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The 90+ Study, co-led by UCI MIND faculty members Drs. Claudia Kawas and Maria Corrada, will be featured in the show “60 Minutes” this Sunday, November 22 on CBS. The episode will be a follow-up of the study participants who were featured on the show six years ago and an update on research findings since then. Learn more about the feature in the articles below: Lesley Stahl follows up with nonagenarians from landmark study on aging Is there a secret to living well into your 90s?
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Contributed by UCI News: UCI’s Center for Neural Circuit Mapping is redrawing our understanding of mechanisms underlying several common disorders by Ian Anzlowar, UCI | November 18, 2020 “Our goal is to reveal the molecular changes that occur during the course of Alzheimer’s, impacting learning and memory, and identify a route toward early detection and new drug therapies for the disease,” says Xiangmin Xu, director of UCI’s Center for Neural Circuit Mapping. Steve Zylius / UCI Thanks to Xiangmin Xu and his team at the UCI School of Medicine’s Center for Neural Circuit Mapping, lazy eye, Alzheimer’s and other neurological…
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UCI Consent-to-Contact (C2C) Registry In 2016, UCI MIND launched a local recruitment registry – the UCI Consent-to-Contact (C2C) Registry – to raise awareness of research participation opportunities at UCI (c2c.uci.edu). We are excited to announce that this fall, the UCI C2C went live in Spanish, Korean, Chinese, and Vietnamese to allow more people to access this online tool. Together with our diverse community, we will improve our understanding of Alzheimer's disease and related dementias in diverse populations and find solutions for people of all backgrounds. To learn more about enrolling in C2C, visit c2c.uci.edu > To read more in our latest newsletter, click here…
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Message from the Director Dear Friends of UCI MIND, As the COVID-19 pandemic continues to impact our lives this fall, the fight to solve Alzheimer’s disease and related dementias (ADRD) must charge forward. This November, the U.S. FDA will convene an advisory committee to assess potential approval of Biogen’s aducanumab, a monoclonal antibody in development for treatment of early AD. We will watch closely as aducanumab could be the first new approved drug for AD since 2005. Regardless of the outcome of the meeting and subsequent FDA decision – anticipated in March 2021 – this represents a milestone for…
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Many of us listened intently today as the US Food and Drug Administration convened a panel of expert members of an advisory committee to review the submitted materials for potential approval of Biogen’s candidate treatment for early Alzheimer’s disease, aducanumab. The meeting was notable on many levels. Advocates made clear and compelling demonstrations of why new therapies are so desperately needed for this disease. The experts, however, were equally clear that the available data from a still limited number of studies, only one of which was actually positive, do not meet the current standards for drug approval in the United…
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The FDA will today convene an advisory committee to review and discuss the application submitted by Biogen Inc. for aducanumab for the treatment of early Alzheimer's disease. Though mixed opinions remain about whether the FDA should approve aducanumab at this time, the submission of a new treatment entity for Alzheimer’s disease is nonetheless good news and an important milestone. It has been nearly two decades since a new drug was approved for Alzheimer’s disease and no approved drug can effectively slow or stop the debilitating progression of this fatal neurodegenerative disease. Regardless of the outcome of this specific submission, we…
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Harriet Harris (second row center) and her family after receiving the UCI MIND Award at the 2019 “A December To Remember” gala event For the first time in the event’s decade-long history, the University of California, Irvine Institute for Memory Impairments and Neurological Disorders (UCI MIND)’s A December to Remember gala will raise awareness and funds for Alzheimer’s research in a digital setting. While many sectors remain at a standstill due to the pandemic, nonprofits like UCI MIND know that their mission must march forward. The virtual gala event will take place online on Saturday, Dec. 5 from 5:30-7 p.m.,…
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“Our findings suggest that older individuals experiencing cognitive decline have relatively stable ideological preferences, but these preferences lose their connection to political policy details. Future studies conducted during an election year may shed additional light on how this group of Americans is casting their ballot,” said UCI MIND faculty member Mark Fisher, MD. Study participants were 190 members of The 90+ Study (LINK), a UCI-led longitudinal investigation of the oldest-old, who are those aged 90 and older.
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Charles Limoli FLASH radiation therapy, also called FLASH-RT, can eliminate the debilitating side effects associated with traditional radiation therapy by delivering the same dose in tenths of seconds, and can remove tumors, according to a study published in Clinical Cancer Research. … Charles Limoli, PhD, a researcher and professor of radiation oncology at University of California Irvine It's not unreasonable to expect that in 10 years, this may become a widespread option for radiotherapy patients worldwide."
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Amanda McQuade, graduate student in Mathew Blurton-Jones’ lab at UCI MIND, discusses findings from their new study using induced pluripotent stem cells (iPSC), donated from participants at the UCI Alzheimer’s Disease Research Center, and CRISPR gene editing to improve understanding of the role of immunity in Alzheimer’s disease. Click below to view the video, and access the publication at this link: https://www.nature.com/articles/s41467-020-19227-5 Amanda McQuade, MS Amanda McQuade is a graduate student in the department of Neurobiology and Behavior working with Dr. Mathew Blurton-Jones. Her graduate work focuses on using CRISPR to study risk mutations for Alzheimer’s disease in human…
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The actual number of deaths linked to dementia may be about three times greater than what is reported on U.S. death certificates, according to a recent NIA-supported study. The findings were published online August 24, 2020, in JAMA Neurology. Previous studies have established that doctors and medical examiners may be underreporting Alzheimer’s disease and related dementias as an underlying cause of death on death certificates. To investigate whether the impact from the underreporting was substantial, a research team led by investigators at Boston University compared dementia-related deaths determined by a nationally representative study to what is reported on death certificates.…
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UC San Francisco, UC Davis, UC Irvine, National Asian Pacific Center on Aging (NAPCA), International Children Assistance Network (ICAN) in partnership with over twenty community partners serving diverse Asian Americans and Pacific Islanders (AAPI) communities in California and nationwide, is pleased to announce the launch of the Collaborative Approach for AAPI Research and Education (CARE) research registry. The CARE registry team reflect multiple diverse AAPI cultures and languages. CARE is an opportunity for AAPI to participate in important research that may affect ourselves, our parents, children and grandchildren. Some of the important research may contribute to finding cures for and/or ways to…
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Congratulations to UCI MIND investigators, Drs. Elizabeth Head and Mark Mapstone, on earning a 5-year $100 million grant to study biomarkers for Alzheimer’s disease in people with Down syndrome. The Alzheimer’s Biomarker Consortium – Down Syndrome (ABC-DS) evolved from the longstanding contributions of Dr. Ira Lott and Eric Doran who had the insight to include older people with Down syndrome in Alzheimer’s disease research. People with Down syndrome are at very high risk for Alzheimer disease as their extra copy of chromosome 21 leads to accelerated amyloid buildup with aging. The new grant will help researchers improve understanding of the unique disease progression…
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Alzheimer syndrom screening.The presentation is made by me based on real scientific knowledge in the public domain. (3-minute listen) After cases began emerging worldwide, thousands of clinical trials unrelated to COVID-19 were paused or canceled amid fears that participants would be infected. But now, some researchers are finding ways to carry on in spite of the coronavirus. "It's been a struggle of course," says Joshua Grill, who directs the Institute for Memory Impairments and Neurological Disorders at the University of California, Irvine. "But I think there's an imperative for us to find ways to move forward."
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Congratulations to Maria Shriver for being selected as Variety's Entertainment Philanthropist of the Year for her trailblazing Alzheimer’s advocacy! Maria Shriver UCI MIND is honored to partner with Shriver and her organization, the Women's Alzheimer's Movement (WAM), to unravel why 2 out of every 3 people with Alzheimer’s are women. Thanks to Shriver and other local philanthropists, the UCI MIND-WAM Women’s Initiative has now awarded $400,000 to UCI scientists for sex and gender disparities research. Variety: “So much of my work is about awareness, prevention, funding of research and trying to educate people about something they think they don’t have…
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"We'll likely continue to see a surge of cases in the fall and over the holidays," says Karen Edwards, a professor and epidemiologist at the University of California, Irvine. "If you must travel, be sure to follow all recommendations, including checking with destinations and events you plan to attend to be sure that travel to that destination or event is still possible. Cancel your trip if you have any symptoms of COVID-19 or concerns about risk of infection."
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Irvine, Calif. – October 15, 2020 – The National Institutes of Health has awarded a team of researchers, led by the University of California, Irvine’s Xiangmin Xu, PhD, a five-year, $3 million grant for a project titled, “Single-Cell Analysis of Aging-Associated 4D Nucleome in the Human Hippocampus.” Now, as part of the 4D Nucleome consortium, Xu, a professor of anatomy and neurobiology and director of the Center for Neural Circuit Mapping at the UCI School of Medicine, together with MPIs, Carl Wayne Cotman, PhD, a professor of neurology and founding director of the UCI Institute for Brain Aging and Dementia,…
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“There are many misperceptions of what ‘capacity to vote’ is,” said Charles Sabatino, director of the American Bar Association Commission on Law and Aging. “Incapacity to follow a recipe and cook dinner doesn’t mean incapacity to vote. The inability to remember your grandchildren’s names doesn’t mean you can’t vote.” What is required — as the commission and the Penn Memory Center point out in a new guide — is the ability to express a preference. “Can you pick among the choices?” said Dr. Jason Karlawish, a geriatrician and co-director of the Penn Memory Center. “That’s it.”
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Contributed by Jean Paul Chadarevian & Amanda McQuade Dr. Emmanuelle Charpentier and Dr. Jennifer A. Doudna make history as the first all-female team to be awarded the Nobel Prize in Chemistry for their pioneering discovery of CRISPR-Cas9, a highly specific and efficient genome editing technology. Emmanuelle Charpentier and Jennifer A. Doudna (Photo by /Invision/AP) Charpentier, Director at the Max Planck Institute for Infection Biology in Berlin, and Doudna, biochemist at the UC Berkeley, first described the CRISPR-Cas9 system in their 2012 publication in Science. CRISPR, or Clustered Regularly Interspaced Short Palindromic Repeats, was first observed in the bacterial immune system.…
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The novel coronavirus pandemic and a US Postal Service slowdown may not be the only hurdles facing people with dementia who want to vote in the 2020 general election. Nearly 6 million people in the US have some form of the condition, the US Centers for Disease Control and Prevention estimates, and they represent almost 2.5% of the 253.8 million US residents who are of voting age. The oldest voters, those aged 60 years or older, are more likely to vote than younger age groups, according to the United States Elections Project; the lion’s share of people with dementia fall…
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Epidemiology professor Karen Edwards, department of Public HealthSteve Zylius / UCI UC Irvine is providing consulting services to private businesses to develop rules and procedures to keep employees and customers safe from COVID-19 as the economy starts to open up. “As the only program in public health in Orange County, we have an obligation to assist our community,” UCI professor Karen Edwards said in a press release. “I think there’s a gap in this area for us to step up and offer these types of services. This has the potential to have a major positive impact.” Orange County was on…
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Contributed by S. Ahmad Sajjadi, MD, PhD Alzheimer’s disease is and will likely remain the commonest cause of dementia. A less well-known fact, however, is that there are also other dementia causing pathologies that are commonly referred to as Alzheimer’s disease related dementia (ADRD). While the scientific community is warming up to the idea that it should consider these other causes in all dementia related research, there is a pressing need for the wider community to be informed about them. These alternative causes of dementia are often age dependent. In people who are younger than 65 years old, a…
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The president is hospitalized and reporters are fighting for basic facts. What should elderly leaders — many of America’s top politicians are over 80 — reveal about their health? “It will help if reporters are medically knowledgeable, and ask the right questions, e.g. blood pressure, heart rhythm, sleep disorders,” Dr. Mark Fisher, a professor of neurology and political science at the University of California, Irvine, told me on Sunday. “The more specific and precise questions reporters ask, the better. A robust fund of knowledge by the reporter is a great advantage.”
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5TH ANNUAL HUNTINGTON'S DISEASE EDUCATIONAL SYMPOSIUM SATURDAY, OCTOBER 3rd, 2020, 1:00 - 3:00 PM Join us for the 2020 Huntington's Disease Educational Symposium! Due to health concerns over the current COVID-19 pandemic, this year we will be hosting a "virtual" educational symposium. There is no cost to participate, but you must pre-register. REGISTER HERE: https://uci.zoom.us/webinar/register/WN_ekBdNftFT7OpZJmERKEBpg Once registered, you will receive an email confirmation with Zoom call-in details for the symposium. Questions? Please contact: Frances Saldana 714-393-8095 Franceshdcare@gmail.comor ucimedia@uci.edu MODERATOR: Peter Donovan, PhD, Professor, Developmental and Cell Biology, School of Biological Sciences and Biological Chemistry, School of Medicine, University of California, Irvine.…
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My 87-year-old mom has Alzheimer's disease in the midst of COVID-19. Right now, that means I can only see her when her Bronx nursing home connects us on Skype. Our Internet connection is sound, but mentally, she is in the grips of this disease. All she can do is just look at me for a few minutes at a time, as I try to get her to remember me. Ramona Latty, talking to her daughter Yvonne over Skype from her nursing home at the beginning of the pandemic. Courtesy of Yvonne Latty "Mommy, it's me, your daughter, tu hija," I…
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More than 5 million people of all ages are living with Alzheimer's in America and that number is expected to rise to nearly 14 million by the 2050. According to the Alzheimer's Association, Alzheimer's Disease is the sixth leading cause of death in this country — killing more Americans than breast cancer and prostate cancer combined. However, research presented at the Alzheimer's Association International Conference (AAIC) shows clear data that improving lifestyle factors can influence the development and the progression of Alzheimer's disease. Here are eight ways to reduce your risk of this devastating disease: Add more fruits and vegetables…
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WASHINGTON, Sept. 24, 2020 —The American Bar Association Commission on Law and Aging and the University of Pennsylvania’s Penn Memory Center released a new guide for assisting voters who have cognitive impairments, Assisting Cognitively Impaired Individuals with Voting: A Quick Guide. Click link to learn more.
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Webinar Monday, September 28 @ 11 AM PST. This webinar will focus on how social isolation and loneliness affect older adults’ health and well-being, particularly amid the unique challenges of the COVID-19 pandemic. The webinar will also address social isolation and loneliness in the context of Alzheimer’s disease and related dementias, emphasize the impact of health disparities, and provide information on potential interventions and mitigating technologies.
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UCI MIND is part of a national network of 31 Alzheimer's Disease Research Centers (ADRC), designated NIH Centers of Excellence, working collaboratively to solve Alzheimer's disease and related dementias, to provide support to families affected, and to educate the public about research. The network, established in 1984, welcomes four new "exploratory" centers that aim to expand current ADRC initiatives with underrepresented populations such as African Americans, Native Americans, and people living in rural communities. Click here to learn more about our national network >
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COVID-19 is a novel disease requiring rapid responses and lifestyle changes on multiple fronts. Learn about government information and resources for the public below. Visit your state health department website for the latest coronavirus information, resources, and guidance in your area.
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The UCI Sue & Bill Gross Stem Cell Center, led by UCI MIND faculty member Dr. Aileen Anderson, hosted part 2 of their expert panel on the state of COVID-19 on September 1. Topics include: Introduction to SARS2-CoV/COVID-19 from Dr. Ming Tan Current status of testing for COVID-19 from UCI MIND faculty member, Dr. Ed Monuki Back to school, wearing masks and public health from Dr. Dan Cooper ASCC’s convalescent plasma and trials for COVID-19 from Dr. Daniela Bota View the complete panel recording below:
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Co-directed by Dr. Joshua Grill, director of UCI MIND, and Dr. Rema Raman, director of biostatistics at USC Alzheimer’s Therapeutic Research Institute, the inaugural class of IMPACT-AD launches this week. The novel program will educate 35 professionals and researchers at various career stages on conducting rigorous, cutting-edge Alzheimer’s clinical trials.
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UCI MIND Leadership Council Member, Steve O'Leary, discusses his journey with Alzheimer's disease on Voices of Resilience hosted by Rick Milenthal. Steve changed his life, sold his business, and altered his priorities when his wife of 40 years was diagnosed with early onset Alzheimer’s. After losing Patty just over three years ago, he’s dedicated his life to finding a cure and helping others navigate the devastating impacts of the disease. Click here to listen to the PODCAST >
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The 31st Annual SoCal Alzheimer’s Research Conference goes LIVE tomorrow, September 10th at 8:00 AM PST. Join us to learn about the latest technology in Alzheimer’s research and care. Engage in live Q&A with world-renowned experts. Visit conference.mind.uci.edu for details and live viewing options. Thank you to our sponsors: Belmont Village Senior Living Aliso Viejo Biogen CalOptima CareAssist Services Caregiver Resource Center OC Caring Companions at Home Companion Hospice DevaWorld by mentia Granny's Place, Inc. Housecall Doctors Medical Group Independence at Home LivHome Optimal Hospice Care Syrentis Clinical Research
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To our valued patients, families and community, The health and well-being of Orange County residents remains all of our organizations’ top priority — and that has never been more true than during the COVID-19 pandemic. That’s why we formed a consortium earlier this year to work together to inform our community about best practices to prevent the spread of COVID-19, including the use of masks. We are joining together to express our gratitude for all you have done — and continue to do — to slow the spread of COVID-19 in our community. We know this environment has not been…
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This September, UCI Brain is leading a virtual campus campaign for World Alzheimer’s Month, featuring labs and individuals at UCI who are expanding our understanding of Alzheimer’s disease and related dementias. Launched in 2012, World Alzheimer's Month is the international campaign by Alzheimer's Disease International (ADI) to raise awareness and challenge the stigma surrounding dementia, which now affects 50 million people worldwide. To learn about the innovative work being done at UCI to combat Alzheimer's disease, tune in to social media throughout the month: @ucibrain @ucirvinemind @ucimind. In this video, graduate student and REMIND co-leader Amanda McQuade shares about stem…
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UCI MIND announces the two new recipients of grant funding from the UCI MIND - Women's Alzheimer's Movement (WAM) Women's Initiative: Sara Mednick, PhD, Assoc. Professor of Cognitive Science at UCI and Liz Chrastil, PhD, Asst. Professor of Neurobiology & Behavior at UCI. The Initiative, a partnership launched in 2017 between UCI MIND and WAM founded by Maria Shriver, provides funding to UCI researchers to help answer why 2/3 people with Alzheimer's disease are women.
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Tomorrow, September 1 at 11 AM PST, UCI MIND will announce the latest award recipients of the UCI MIND - Women's Alzheimer's Movement (WAM) Women's Initiative live on Facebook. The two researchers will share about their motivation for studying Alzheimer's disease and their projects to improve understanding of sex disparities. They will also address questions from live viewers. When: Tuesday, September 1 @ 11 AM PST Where: UCI MIND's Facebook Page (@UCIrvineMIND) If you miss the live broadcast, it will be accessible on our Facebook page, YouTube channel, and Blog afterward.
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Message from the Director Dear Friends of UCI MIND, Summer of 2020 has been unlike any summer before. We are all struggling to adjust to life amid a global pandemic that has been upending our lives for several months. Many of us have been unable to see our loved ones, others have lost our treasured family members. At the end of this newsletter, we offer some guidance from the Centers for Disease Control for caregivers of people living with dementia. Despite COVID-19, the work of UCI MIND continues. This includes important milestones. Most notably, the NIH selected UCI MIND…
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In 1964, Keith Swayne, then a graduate student at UC Berkeley, went on a blind date with local school teacher Judy Kjellberg. He was head over heels, and just two weeks later, he proposed to her. Over the next 50 years, they raised a son and daughter, pursued their careers and engaged with the Orange County community through nonprofit work. Judy created the Orange County Community Foundation in 1989, laying the groundwork for it to grow into a change-maker with assets today in excess of $400 million, supporting various causes across the region. But during the final decade of their…
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Across the country, older adults with acute and chronic conditions have hesitated to visit medical offices, given that people over age 65 are at greater risk for severe illness from exposure to the novel coronavirus outbreak. “Our patients need to know that we’re very protective of their safety,” says Dr. Lisa Gibbs, director of the UCI Health SeniorHealth Center. Photo credit: UCI Health But people with these conditions — such as diabetes, hypertension and heart ailments that require regular monitoring — are also vulnerable to experiencing complications from their underlying disease if care is postponed, says Dr. Lisa Gibbs, medical director…
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