ARE YOU OR IS SOMEONE YOU KNOW EXPERIENCING MEMORY LOSS?
Researchers at UCI and UCLA are conducting a new study to test whether high doses of nicotinamide (a component of vitamin B3) can halt or reverse neurofibrillary tangles in Alzheimer’s disease.
Lead researcher: Joshua Grill, PhD and Steven Tam, MD
Study Title: A Phase 2, Proof-of-Concept, Double-Blind-Randomized, Placebo-Controlled Adaptive Design Trial of Nicotinamide in MCI due to AD and Mild AD Dementia
Purpose of Study: To evaluate whether nicotinamide, also known as vitamin B3 or niacinamide, can reduce phosphorylation or “over-processing” of tau (the protein that accumulates in neurofibrillary tangles) in people with Mild Cognitive Impairment or mild Alzheimer’s disease (AD) dementia.
Eligibility: Men and women, aged 50 years and above and diagnosed with Mild Cognitive Impairment or mild dementia due to Alzheimer’s disease.
Location: UCI Campus (1100 Gottschalk Medical Plaza, Irvine; ICTS at Hewitt Hall, Irvine and Newport Diagnostic Center, Newport Beach); UCLA (Center for Neurotherapeutics UCLA Medical Center 300 Medical Plaza, Westwood Blvd Los Angeles)
Time Commitment: Screening Phase (may be up to 6o days) and Treatment Phase (4 visits over a 12 month period)
Anticipated Benefits: You may or may not benefit from participating in this study. The information collected from this study may increase knowledge regarding the treatment of Alzheimer’s disease and help people in the future.
Compensation: Participants are eligible to receive the following compensation in cash during the course of this study:
- Visit 1 completion: $50
- Visit 2 completion: $50
- Visit 3 completion: $50
- Visit 4 completion: $100
The grand total compensation for this study is a maximum of $250 in cash
Reimbursement: Participants will not be reimbursed for travel-related expenses.
Contact name, UCI Department, Phone Number and Email:
Clinical Trials Research Inquiry Coordinator
Institute for Memory Impairments and Neurological Disorders (UCI MIND)
Alzheimer’s Disease Research Center (ADRC)
1100 Gottschalk Medical Plaza
Irvine, CA 92697-4285
UCI IRB Approved: 05-25-2018 | MOD# 24074 | HS# 2016-3246