Clinical Core

Within the ADRC, the Clinical Core’s primary responsibility is to evaluate both people with and without cognitive problems and follow them at least annually until death to document the normal and pathological brain changes that occur with aging.  Led by Dr. Claudia Kawas, the Clinical Core helps hundreds of families affected by Mild Cognitive Impairment (MCI), Alzheimer’s disease, and related disorders while gathering invaluable data on clinical presentation and progression of brain diseases for use by researchers.

Participants enrolled in the UCI ADRC cohorts, including the Longitudinal Study, the Down Syndrome Program led by Dr. Ira Lott, and The 90+ Study led by Dr. Claudia Kawas, undergo comprehensive at least annual evaluations that include a neurological and physical examination, neuropsychological assessment, brain imaging, lumbar puncture, blood and diagnostic tests, and an interview with a study partner (usually a close family member or friend). Unless cultural or religious beliefs prohibit it, participants are also asked to consider brain donation upon death.  Data collected from participants is shared with Alzheimer’s disease investigators worldwide in a national database, the National Alzheimer’s Coordinating Center (NACC).

Clinical Core Leaders:

For more information on UCI ADRC studies, please contact 949.824.0008 or

Claudia Kawas, MD

Ira Lott, MD

Sample of Core Publications