Southern California Alzheimer’s Disease Research Conference

36th Annual Southern California Alzheimer’s Disease Research Conference
“Nature, Nurture, & Neurodegeneration: Decoding Risk for Dementia”

• Opening remarks:
  Jim McAleer, Alzheimer’s Orange County | Deborah Levy, Alzheimer’s Association, Orange County Chapter | Joshua Grill, PhD, University of California, Irvine

• Nature and Nurture—Each in Their Own Measure

  Kenneth Kosik, MD, University of California, Santa Barbara

• Medical Risk Factors for Alzheimer’s Disease

  Sudha Seshadri, MD, DM University of Texas Health Sciences Center at San Antonio

• Beyond APOE: Advances in Alzheimer’s Genetics Research

  Jennifer Yokoyama, PhD, University of California, San Francisco

• The Invisible Threat: Pollution and Dementia Risk

  Jennifer Weuve, MPH, ScD, Boston University

• A Role for Epigenetics in Alzheimer’s Disease Risk

  Vivek Swarup, PhD, University of California, Irvine

• Learning from Rare Genetic Cases of Alzheimer’s Disease

  Yakeel Quiroz, PhD, Boston University

• Psychiatric Symptoms and Dementia Risk

  Jennifer Gatchel MD, PhD, Massachusetts General Hospital; Harvard Medical School

• Family Panel

  Moderated by Joshua Grill, PhD, University of California, Irvine

• Closing Remarks

  Joshua Grill, PhD, University of California, Irvine

35th Annual Southern California Alzheimer’s Disease Research Conference
“Advance in Dementia Care”

• Opening remarks:
  Patty Barnett Mouton, Alzheimer’s Orange County | Deborah Levy, Alzheimer’s Association, Orange County Chapter | Joshua Grill, PhD, University of California, Irvine
• The first approved disease targeting Alzheimer’s disease therapies
  Aimee Pierce, MD, Oregon Health Sciences University
• Genetic testing in the age of new treatments for Alzheimer’s disease
  Scott Roberts, PhD, University of Michigan
• Pseudomedicine and the marketing of unproven and unapproved stem cell interventions for dementia

  Leigh Turner, PhD, University of California, Irvine
• The first approved treatment for agitation in Alzheimer’s disease
  Lydia Ann, MD, University of California, Irvine
• Access, accuracy, and equity in dementia diagnoses
  Elena Tsoy, PhD, University of California, San Francisco
• Clinical use of blood tests for Alzheimer’s disease
  Suzanne Schindler, MD, Washington University
• The evolution of dementia care
  Lisa Gibbs, MD, University of California, Irvine
• Caregiver panel with Joshua Grill, PhD, University of California, Irvine (Moderator)
• Closing remarks
  Joshua Grill, PhD, University of California, Irvine

34th Annual Southern California Alzheimer’s Disease Research Conference
“Sex and Gender in Dementia Research and Care”

• Opening Remarks:
  Jim McAleer, MPA, Alzheimer’s Orange County | Deborah Levy, Alzheimer’s Association, Orange County Chapter | Joshua Grill, PhD, University of California, Irvine
• Incidence and prevalence of Alzheimer’s disease and related dementias among men and women
  Michelle Mielke, PhD, Wake Forest University
• Sex-specific genetic drivers of Alzheimer’s disease
  Tim Hohman, PhD, Vanderbilt University
• Sex differences in Alzheimer’s disease biomarker progression: the role of APOE

  Beth Mormino, PhD, Stanford University
• Sex differences in Alzheimer’s disease biomarker progression: Sensitive measures of cognition
  Sarah Banks, PhD, University of California, San Diego
• Spatial cognition in men and women in age and Alzheimer’s disease
  Liz Chrastil, PhD, University of California, Irvine
• Sex differences in Alzheimer’s disease treatments
  Amanda Smith, MD, University of South Florida
• Sexual and gender minorities & dementia caregiving
  Jason Flatt, PhD, University of Nevada, Las Vegas
• Caregiver Panel with Joshua Grill, PhD, University of California, Irvine (Moderator)
• Closing Remarks
  Joshua Grill, PhD, University of California, Irvine

33rd Annual Southern California Alzheimer’s Disease Research Conference
“Dementia across the lifespan”

• Opening Remarks:
  Jim McAleer, MPA, Alzheimer’s Orange County | Deborah Levy, Alzheimer’s Association, Orange County Chapter | Joshua Grill, PhD, University of California, Irvine
• Delving into Alzheimer’s disease in Down syndrome – how a lifespan approach can help (slides)
  Elizabeth Head, PhD, Professor, Vice Chair for Research, Pathology, University of California, Irvine
• A Family Matter: Genetics and Alzheimer’s disease (slides)
  Jessica Langbaum, PhD, Co-Director, Alzheimer’s Prevention Initiative, Banner Alzheimer’s Institute
• UCSF Care Ecosystem Program (slides)

  Katherine Possin, PhD, Associate Professor, Neurology, University of California, San Francisco, Weill Institute for Neurosciences, Memory and Aging Center
• UCLA Alzheimer’s and Dementia Care Program (slides)
  Lee A. Jennings, MD, MSHS, Chief and Assistant Professor, University of Oklahoma Health Sciences Center, Reynolds Section of Geriatric Medicine
• Frontotemporal dementias: Clinical description and effort to develop treatments (slides)
  Peter Ljubenkov, MD, Assistant Professor, Neurology, University of California, San Francisco, Weill Institute for Neurosciences, Memory and Aging Center
• Introducing LATE: An important underpinning of dementia in later life (slides)
  S. Ahmad Sajjadi, MD, PhD, Associate Professor, Neurology, Pathology, University of California, Irvine
• Factors contributing to resistance and resilience in the aging population (slides)
  Prashanthi Vemuri, PhD, Professor, Radiology, Mayo Clinic
• Caregiver Panel with Joshua Grill, PhD, University of California, Irvine (Moderator)
• Closing Remarks
  Joshua Grill, PhD, University of California, Irvine

32nd Annual Southern California Alzheimer’s Disease Research Conference
“Alzheimer’s from all angles”

• WELCOME: THE STATE OF DEMENTIA RESEARCH & CARE IN 2021: Joshua Grill, PhD, University of California, Irvine (Moderator) | Jim McAleer, MPA, Alzheimer’s Orange County
• BLOOD TESTS FOR ALZHEIMER’S DISEASE: CLOSER BUT STILL NOT THERE (slides): Sid O’Bryant, PhD, University of North Texas
• EXPLORING SEX DIFFERENCES & THE POSSIBILITY OF PROTECTIVE GENES: Dena Dubal, MD, PhD, University of California, San Francisco
• VIRAL INFECTIONS & ALZHEIMER’S DISEASE (slides): Thomas Lane, PhD, University of California, Irvine
• NEIGHBORHOOD DISPARITIES: HOW WHERE YOU LIVE MIGHT IMPACT YOUR BRAIN HEALTH (slides): Amy Kind, MD, PhD, University of Wisconsin
• FUTURE FOCUSED: TREATMENT ADVANCEMENTS IN ALZHEIMER’S (slides): Gregory Jicha, MD, PhD, University of Kentucky

31st Annual Southern California Alzheimer’s Disease Research Conference
“tackling DEMENTIA with TECHNOLOGY”

• Welcome: The State of Dementia Research & Care in 2020: Joshua Grill, PhD, University of California, Irvine (Moderator) | Jim McAleer, MPA, Alzheimer’s Orange County
• Computerized Cognitive Testing (slides): Dorene M. Rentz, PsyD, Harvard Medical School
• Gaming for Brain Training (slides): Craig Stark, PhD, University of California, Irvine
• Sleep Gadgets (slides): Ruth Benca, MD, PhD, University of California, Irvine
• AI @ Autopsy: Edwin Monuki, MD, PhD, University of California, Irvine
• Smart Tech for In-Home Care (slides): Alex Mihailidis, PhD, PEng, University of Toronto, Canada

30th Annual Southern California Alzheimer’s Disease Research Conference
“30 Years of Discovery: Hope on the Horizon”

• Welcome: 30 Years of Discovery: Joshua Grill, PhD, University of California, Irvine | Jim McAleer, MPA, Alzheimer’s Orange County | Carl Cotman, PhD, University of California, Irvine
• Lessons Learned of Mice (& Men) (slides): Frank LaFerla, PhD, University of California, Irvine
• Advances in Clinical Diagnosis (slides): David Sultzer, MD, University of California, Irvine
• Gifted Brains Yield Priceless Gains (slides): Julie Schneider, MD, MS, Rush University
• Brain Scans & Biomarkers (slides): William Jagust, MD, University of California, Berkeley
• Panel: Hope on the Horizon: Moderator: Joshua Grill, PhD, University of California, Irvine
• Detection in the Digital Era (slides): Rhoda Au, PhD, MBA, Boston University
• Risk & Prevention Across the Lifespan (slides): Rebecca Gottesman, MD, PhD, Johns Hopkins University

29th Annual Southern California Alzheimer’s Disease Research Conference
“Trials Today, Treatments Tomorrow”

• Welcome: Frank LaFerla, PhD, Jim McAleer, MPA, Joshua Grill, PhD
• Alzheimer’s Clinical Trials: History & Lessons (slides): Jeffrey Cummings, MD, ScD, Cleveland Clinic Lou Ruvo Center for Brain Health
• How Clinical Trials Work (slides): Daniel Gillen, PhD, UC Irvine
• Treatment Development for Neuropsychiatric Symptoms in Alzheimer’s Dementia: Where are We Headed? (slides): Constantine Lyketsos, MD, MHS, Johns Hopkins
• Clinical Trials of Dietary Interventions (slides): Martha Clare Morris, ScD, Rush University
• How to Choose a Clinical Trial: Research Participant Panel: Moderated by Joshua Grill, PhD, UC Irvine
• Prevention Trials for Cognitive Loss and Alzheimer’s Disease: Finding an Invested Patient Population (slides): Mary Sano, PhD, Mount Sinai
• Redefining Alzheimer’s Disease: The Role of Clinical Trials: Jason Karlawish, MD, University of Pennsylvania

28th Annual Southern California Alzheimer’s Disease Research Conference
“The Elephant in the Room: Sensitive Subjects in Dementia Care”

• Welcome and Opening: Frank LaFerla, PhD, Patty Mouton, and Joshua Grill, PhD
• Driving Under the Influence of Dementia: Brian Ott, MD, Brown University
• Elder Abuse and Neglect: Laura Mosqueda, MD, USC
• Sex and Intimacy in Dementia: Mehrdad Ayati, MD, Stanford University
• Behavioral and Psychiatric Symptoms: David Sultzer, MD, UCLA
• Dementia and the End of Life: Lynn Flint, MD, UCSF
• Physician Orders for Life Sustaining Treatment: Patty Mouton, Alzheimer’s Orange County
• Physician Aid-in-Dying: Joshua Grill, PhD, Fay Blix, Esq, Ruth Benca, MD, Lynn Flint, MD, Brian Ott, MD

27th Annual Southern California Alzheimer’s Disease Research Conference:
“Advances in Dementia Research Across Unique Populations”

• Frank LaFerla, PhD, Jim McAleer, MPA, and Joshua Grill, PhD – Welcome and Opening
• Tiffany Chow, MD, MS – Cognitive Decline Among the Elderly: Differential Diagnosis
• Howard Rosen, MD – Frontotemporal Dementia
• Neill Graff-Radford, MD – Lewy Body Dementia
• Joshua Grill, PhD – Dementia Caregiver Panel
• Ira Lott, MD – Dementia and Down Syndrome
• Maria Corrada, ScD, ScM – Dementia and the Oldest Old: Results from The 90+ Study
• Charles Bernick, MD, MPH – Dementia and Head Trauma

26th Annual Southern California Alzheimer’s Disease Research Conference:
“Health Brain Aging: Considering the Possibilities”

• Maria C. Carillo, PhD – Healthy Brain Aging: Considering the Possibilities (Click here to download slides)
• Alon Y. Avidan, MD, MPH – Sleep Disturbances and Dementia: There Will Be Plaque (Click here to download slides)
• Jessica Langbaum, PhD – Cognitive Training Interventions for Delaying Cognitive Decline (Click here to download slides)
• Joshua Grill, PhD – Prevention Clinical Trials: Taking the Next Steps Responsibly (Click here to download slides)
• Daniel A. Nation, PhD – The Role of Vascular Aging in Cognitive Decline and Alzheimer’s Disease (Click here to download slides)
• Carl Cotman, PhD – Exercise and Alzheimer’s Disease Research (Click here to download slides)
• Kelli Sharp, PhD – Memory and Movement Interactive Session (Click here to download slides)

25th Annual Southern California Alzheimer’s Disease Research Conference:
“The Future of Alzheimer’s Disease Research”

• Welcome and Opening
• Howard Federoff, MD, PhD – Predicting Future Cognitive Impairment in Older Adults with Blood Plasma Lipids (Click here to download slides)
• Pete Nelson, MD, PhD – Alzheimer’s Disease Mimics: Common and Under-Appreciated Causes of Dementia (Click here to download slides)
• Gerard Schellenberg, PhD – What Genetics and Rare-Variant Studies Have Told Us About Alzheimer’s Disease (Click here to download slides)
• Ken Kosik, MD – Clinical Trials: What We’ve Learned from Columbian Families (Click here to download slides)
• Cordula Dick-Muehlke, PhD – MCI Panel: Living with Cognitive Impairment (Click here to download slides)
• Kim Green, PhD – Microglia as a Therapeutic Target in Alzheimer’s Disease (Click here to download slides)
• Michael Yassa, PhD – Imaging as a Research Tool in Alzheimer’s Disease (Click here to download slides)
• Tracy Young-Pearse, PhD – Stem Cells and the Study of Neurodegeneration (Click here to download slides)
• Liana Apostolova, MD – Imaging for Diagnosing Dementia (Click here to download slides)
• Aimee Pierce, MD – Alzheimer’s Disease and Language (Click here to download slides)
• Thomas Montine, MD, PhD – New Neuropath Guidelines and the Importance of Brain Donation (Click here to download slides)

24th Annual Southern California Alzheimer’s Disease Research Center:
“Countdown to 2025: Progress on Ending Alzheimer’s Disease”

• Welcome and Opening – Year in Review
• Petersen – National Plan to Address Alzheimer’s Disease: What’s Next?
• Fleisher – Neuroimaging: An Early Diagnostic Marker
• Tenner – Inflammation as a Therapeutic Target in Alzheimer’s Disease
• Kawas – Preventing Alzheimer’s Disease: What We’ve Learned from the Oldest Old
• Petersen – DSM-V: Renaming Dementia
• Bettcher – Best Practices in Diagnosis and Treatment of Alzheimer’s Disease
• Morris – DIAN: Understanding Alzheimer’s Disease in Persons with Causative Genetic Mutations
• Blurton-Jones – New Hope: Stem Cell Therapy in Alzheimer’s Disease
• Glabe – The Role of Amyloid in the Development and Treatment of Alzheimer’s Disease
• Cribbs – Progress in Immunotherapy for Treating Alzheimer’s Disease
• Ask the Doc Forum – All Speakers

23rd Annual Southern California Alzheimer’s Disease Research Conference:
“Beyond Memory: The Behavioral and Psychiatric Symptoms of Dementia”